Synthesis of Tritium-Labeled Non-Natural Analogs of Purine and Pyrimidine Nucleosides

Convenient preparative ways to synthesize tritium-labeled non-natural derivatives containing the cytosine and guanine moieties have been developed. The main distinction of these compounds from those already known consists in that they contain a chiral center. The tritium-labeled 2'-desoxy-3...

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Bibliographic Details
Published in:Radiochemistry (New York, N.Y.) N.Y.), 2020-02, Vol.62 (2), p.255-259
Main Authors: Sidorov, G. V., Myasoedov, N. F.
Format: Article
Language:English
Subjects:
Bromine compounds
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Nuclear Chemistry
Solid phases
Tritium
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Summary:Convenient preparative ways to synthesize tritium-labeled non-natural derivatives containing the cytosine and guanine moieties have been developed. The main distinction of these compounds from those already known consists in that they contain a chiral center. The tritium-labeled 2'-desoxy-3'-oxacytidine can was synthesized by the reaction of catalytic dehalogenation in solution of the corresponding 5-bromine-substituted compound; for 6-aminocyclopropyl-2'-desoxy-3'-oxaguanosine, the reaction of catalytic heterogeneous catalytic exchange in solution was used; for rest of compounds, the reaction of solid-phase catalytic hydrogenation (SCH) was employed.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362220020149