A four-component Biginelli reaction: new opportunities for the synthesis of functionalized pyrimidines

Methyl 5-aroyl-6-aryl-4-methoxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates were synthesized by four-component Biginelli reaction of methyl aroylpyruvate, aromatic aldehyde, urea (thiourea), and MeOH in the presence of NaHSO 4 . The products were obtained in moderate to high yields.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-03, Vol.56 (3), p.339-346
Main Authors: Gein, Vladimir L., Zamaraeva, Tatiana M., Gorgopina, Ekaterina V., Dmitriev, Maksim V.
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Carboxylates
Chemistry
Chemistry and Materials Science
Nitriles
Organic Chemistry
Pharmacy
Pyrimidines
Urea
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Summary:Methyl 5-aroyl-6-aryl-4-methoxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates were synthesized by four-component Biginelli reaction of methyl aroylpyruvate, aromatic aldehyde, urea (thiourea), and MeOH in the presence of NaHSO 4 . The products were obtained in moderate to high yields.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-020-02665-w