Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment

We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression vari...

Full description

Saved in:
Bibliographic Details
Published in:Biocell 2019, Vol.43 (1), p.29-35
Main Authors: RAM蚏EZ-FERN罭DEZ, Odin, CACOPARDO, Ludovika, LEON-MANCILLA, Benjam韓, COSTA, Joana
Format: Article
Language:English
Subjects:
Bioreactors
Compression
Mimicry
Nutrients
Peristalsis
Permeability
Rhythms
Small intestine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic movement. This custom-designed presents a semipermeable membrane bioreactor, with peristaltic flow and compression variation that allows adjustment of luminal flow rate. In addition, this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable channel. This dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with the previously described in vitro small intestinal models, providing a more representative model of the small intestine.
ISSN:1667-5746
0327-9545
DOI:10.32604/biocell.2019.04790