Synergism of flavonoids with bacteriostatic action against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922

In our previous studies, bacteriostatic action of flavonoids against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922 was demostrated. In the present work synergism of their combinations in order to improve the bacteriostatic action against the same microorganisms was determined. T...

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Bibliographic Details
Published in:Biocell 2006-01, Vol.30 (1), p.39-42
Main Authors: Alvarez, Maria de los A, Debattista, Nora B, Pappano, Nora B
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Bacteriostats
Drug Synergism
E coli
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - growth & development
Flavonoids
Flavonoids - administration & dosage
Microbial Sensitivity Tests
Minimum inhibitory concentration
Quercetin
Quercetin - administration & dosage
Rutin
Rutin - administration & dosage
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
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Summary:In our previous studies, bacteriostatic action of flavonoids against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922 was demostrated. In the present work synergism of their combinations in order to improve the bacteriostatic action against the same microorganisms was determined. The experiences were made in nutritive broth, maintaining constant one drug concentration (20 microg/ml) and increasing the other one. A turbidimetric kinetic method was used and by means of a mechanism previously proposed, the minimal inhibitory concentrations (MIC's) of each flavonoid combination were determined. The MIC's for assayed combinations against S. aureus were: variable morin - constant rutin: 157.44 microg/ml and variable quercetin - constant morin: 29.9 microg/ml. The values obtained against E. coli were: variable morin - constant rutin: 78.5 microg/ml; variable quercetin - constant rutin: 47.4 microg/ml; variable quercetin - constant morin: 25 microg/ml; variable morin - constant quercetin: 27.4 microg/ml.
ISSN:0327-9545
1667-5746
DOI:10.32604/biocell.2006.30.039