Umbilical vein injection of 400 versus 800 μg misoprostol for the treatment of retained placenta: A multicenter, randomized double‐blind controlled trial

Aims This trial was conducted to determine the efficacy of umbilical vein injection of 400 versus 800 μg misoprostol to deliver retained placenta and to compare both regimens regarding the time of placental delivery and amount of vaginal blood loss. Methods A double‐blind, multicenter randomized cli...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2020-05, Vol.46 (5), p.727-735
Main Authors: Alalaf, Shahla K., Al Tawil, Namir G., Jawad, Ariana K., Mahmoud, Maryam B., Muhamad, Bahar Q., Abdul Rahman, Khansa H., Sileem, Sileem A., Hassan, Jinan N., Ameen, Khalida M., Mustafa, Samira A., Bawadikji, AbdulKader A.
Format: Article
Language:English
Subjects:
Adult
Blood
Dose-Response Relationship, Drug
Double-Blind Method
Double-blind studies
Egypt
Female
Hemoglobin
Humans
Injection
Injections, Intravenous
Iraq
manual removal of placenta
Misoprostol
Misoprostol - administration & dosage
Oxytocics - administration & dosage
Placenta
Placenta, Retained - drug therapy
Pregnancy
retained placenta
Time Factors
Umbilical vein
Umbilical Veins
Vagina
Young Adult
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Summary:Aims This trial was conducted to determine the efficacy of umbilical vein injection of 400 versus 800 μg misoprostol to deliver retained placenta and to compare both regimens regarding the time of placental delivery and amount of vaginal blood loss. Methods A double‐blind, multicenter randomized clinical trial was undertaken in four teaching hospitals in the North of Iraq and Al‐Azhar University Hospital in Egypt, from March 2016 to May 2019. Group I (274 women) received 400 μg misoprostol and group II (249 women) received 800 μg misoprostol. Data regarding the time of placental separation and amount of vaginal blood loss were analyzed and proportions were compared between groups using Chi‐squared test. Mean values were compared using the Student's t‐test. The Mann–Whitney test was used to determine the median of vaginal blood loss. Results The proportion of placental separation was 84.3% among women in group I and 86.7% of women in group II. The mean time of placental separation was 18.86 ± 234.2 and 17.86 ± 213.09 min in groups I and II, respectively (P
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.14232