Loading…
Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?
Background Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure t...
Saved in:
Published in: | Environmental sciences Europe 2020-12, Vol.32 (1), Article 74 |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3 |
---|---|
cites | cdi_FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3 |
container_end_page | |
container_issue | 1 |
container_start_page | |
container_title | Environmental sciences Europe |
container_volume | 32 |
creator | Ceretti, Elisabetta Donato, Francesco Zani, Claudia Villarini, Milena Verani, Marco De Donno, Antonella Bonetta, Sara Feretti, Donatella Carducci, Annalaura Idolo, Adele Carraro, Elisabetta Covolo, Loredana Moretti, Massimo Palomba, Giacomo Grassi, Tiziana Bonetti, Alberto Bonizzoni, Silvia Biggeri, Annibale Gelatti, Umberto |
description | Background
Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure to urban air pollutants and micronucleus (MN) frequency, as a biomarker of chromosomal damage, in buccal cells of children for supporting implementation and updating of environmental policy and legislation.
Methods
This prospective epidemiological cohort study was carried out on 6- to 8-year-old children living in five Italian towns with different levels and features of air pollution. Exfoliated buccal cells of the children were sampled twice, in winter and spring, obtaining 2139 biological samples for genotoxicological investigation. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants’ concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity.
Results
Positive and statistically significant associations were found between MN frequency and PM10, PM2.5, benzene, SO
2
and ozone. The increment of the risk of having MN in buccal cells for each μg/m
3
increase of pollutant concentration was maximum for benzene (18.9%, 95% CIs 2.2–38.4%) and modest for the other pollutants (between 0.2 and 1.4%). An increased risk (between 17.9% and 59.8%) was found also for exposure to PM10, benzene and benzo(a)pyrene levels higher than the threshold limits.
Conclusions
Some air pollutants are able to induce chromosomal damage in buccal cells of children even at concentrations below present EU/WHO limits. This type of biological effects may be indicative of the environmental pressure which populations are exposed to in urban areas. |
doi_str_mv | 10.1186/s12302-020-00352-3 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2399630618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2399630618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3</originalsourceid><addsrcrecordid>eNp9UclqHDEQbUIMMbZ_IKcCnzvR0qsvwQxjxzAmwcRnoZZKbhmN1JHUgfmbfGo0mZDcUpd6VL3l8KrqPSUfKB26j4kyTlhNGKkJ4S2r-ZvqnNGR1E1P27d_MenfVVcpvZIyLRv6pj2vfj5hWl1OYGLYQ54RtmsMC0oPz94GD4-3X7cbsXu424IKc4gZUl71AcpL2ghLcG7NR6L0GtRcXEIKe-lAy718QbC-XK3TEf0NyIiwrJOzCmaULs9HvVUWE6TVmCPy2R1giSGjyvYHfrqszox0Ca_-7Ivq-W77bfO53n25f9jc7mrVsC7XXac7bdppMFoZM_TDxDhTSiKTw9SjVqQhvWKtGTX2vSZGMt1oo8ZJo6QD8ovq-uRbsr-vmLJ4DWv0JVIwPo4dJx0dCoudWCqGlCIasUS7l_EgKBHHMsSpDFHKEL_LELyI-EmUCtm_YPxn_R_VL8nOkPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2399630618</pqid></control><display><type>article</type><title>Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?</title><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><creator>Ceretti, Elisabetta ; Donato, Francesco ; Zani, Claudia ; Villarini, Milena ; Verani, Marco ; De Donno, Antonella ; Bonetta, Sara ; Feretti, Donatella ; Carducci, Annalaura ; Idolo, Adele ; Carraro, Elisabetta ; Covolo, Loredana ; Moretti, Massimo ; Palomba, Giacomo ; Grassi, Tiziana ; Bonetti, Alberto ; Bonizzoni, Silvia ; Biggeri, Annibale ; Gelatti, Umberto</creator><creatorcontrib>Ceretti, Elisabetta ; Donato, Francesco ; Zani, Claudia ; Villarini, Milena ; Verani, Marco ; De Donno, Antonella ; Bonetta, Sara ; Feretti, Donatella ; Carducci, Annalaura ; Idolo, Adele ; Carraro, Elisabetta ; Covolo, Loredana ; Moretti, Massimo ; Palomba, Giacomo ; Grassi, Tiziana ; Bonetti, Alberto ; Bonizzoni, Silvia ; Biggeri, Annibale ; Gelatti, Umberto ; MAPEC_LIFE Study Group</creatorcontrib><description>Background
Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure to urban air pollutants and micronucleus (MN) frequency, as a biomarker of chromosomal damage, in buccal cells of children for supporting implementation and updating of environmental policy and legislation.
Methods
This prospective epidemiological cohort study was carried out on 6- to 8-year-old children living in five Italian towns with different levels and features of air pollution. Exfoliated buccal cells of the children were sampled twice, in winter and spring, obtaining 2139 biological samples for genotoxicological investigation. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants’ concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity.
Results
Positive and statistically significant associations were found between MN frequency and PM10, PM2.5, benzene, SO
2
and ozone. The increment of the risk of having MN in buccal cells for each μg/m
3
increase of pollutant concentration was maximum for benzene (18.9%, 95% CIs 2.2–38.4%) and modest for the other pollutants (between 0.2 and 1.4%). An increased risk (between 17.9% and 59.8%) was found also for exposure to PM10, benzene and benzo(a)pyrene levels higher than the threshold limits.
Conclusions
Some air pollutants are able to induce chromosomal damage in buccal cells of children even at concentrations below present EU/WHO limits. This type of biological effects may be indicative of the environmental pressure which populations are exposed to in urban areas.</description><identifier>ISSN: 2190-4707</identifier><identifier>EISSN: 2190-4715</identifier><identifier>DOI: 10.1186/s12302-020-00352-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Air pollution ; Air quality ; Air quality assessments ; Benzene ; Benzo(a)pyrene ; Biological effects ; Biological properties ; Biological samples ; Biomarkers ; Children ; Chromosome aberrations ; Cohort analysis ; Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental law ; Environmental legislation ; Environmental policy ; Epidemiology ; Exposure ; Genotoxicity ; Health policy ; Health risks ; Hydrocarbons ; Investigations ; Legislation ; Outdoor air quality ; Particulate matter ; Poisson density functions ; Pollutants ; Pollution ; Public health ; Pyrene ; Regression analysis ; Regression models ; Statistical analysis ; Statistical methods ; Sulfur dioxide ; Threshold limits ; Urban areas ; Water pollution effects</subject><ispartof>Environmental sciences Europe, 2020-12, Vol.32 (1), Article 74</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3</citedby><cites>FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3</cites><orcidid>0000-0002-4856-5364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ceretti, Elisabetta</creatorcontrib><creatorcontrib>Donato, Francesco</creatorcontrib><creatorcontrib>Zani, Claudia</creatorcontrib><creatorcontrib>Villarini, Milena</creatorcontrib><creatorcontrib>Verani, Marco</creatorcontrib><creatorcontrib>De Donno, Antonella</creatorcontrib><creatorcontrib>Bonetta, Sara</creatorcontrib><creatorcontrib>Feretti, Donatella</creatorcontrib><creatorcontrib>Carducci, Annalaura</creatorcontrib><creatorcontrib>Idolo, Adele</creatorcontrib><creatorcontrib>Carraro, Elisabetta</creatorcontrib><creatorcontrib>Covolo, Loredana</creatorcontrib><creatorcontrib>Moretti, Massimo</creatorcontrib><creatorcontrib>Palomba, Giacomo</creatorcontrib><creatorcontrib>Grassi, Tiziana</creatorcontrib><creatorcontrib>Bonetti, Alberto</creatorcontrib><creatorcontrib>Bonizzoni, Silvia</creatorcontrib><creatorcontrib>Biggeri, Annibale</creatorcontrib><creatorcontrib>Gelatti, Umberto</creatorcontrib><creatorcontrib>MAPEC_LIFE Study Group</creatorcontrib><title>Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?</title><title>Environmental sciences Europe</title><addtitle>Environ Sci Eur</addtitle><description>Background
Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure to urban air pollutants and micronucleus (MN) frequency, as a biomarker of chromosomal damage, in buccal cells of children for supporting implementation and updating of environmental policy and legislation.
Methods
This prospective epidemiological cohort study was carried out on 6- to 8-year-old children living in five Italian towns with different levels and features of air pollution. Exfoliated buccal cells of the children were sampled twice, in winter and spring, obtaining 2139 biological samples for genotoxicological investigation. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants’ concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity.
Results
Positive and statistically significant associations were found between MN frequency and PM10, PM2.5, benzene, SO
2
and ozone. The increment of the risk of having MN in buccal cells for each μg/m
3
increase of pollutant concentration was maximum for benzene (18.9%, 95% CIs 2.2–38.4%) and modest for the other pollutants (between 0.2 and 1.4%). An increased risk (between 17.9% and 59.8%) was found also for exposure to PM10, benzene and benzo(a)pyrene levels higher than the threshold limits.
Conclusions
Some air pollutants are able to induce chromosomal damage in buccal cells of children even at concentrations below present EU/WHO limits. This type of biological effects may be indicative of the environmental pressure which populations are exposed to in urban areas.</description><subject>Air pollution</subject><subject>Air quality</subject><subject>Air quality assessments</subject><subject>Benzene</subject><subject>Benzo(a)pyrene</subject><subject>Biological effects</subject><subject>Biological properties</subject><subject>Biological samples</subject><subject>Biomarkers</subject><subject>Children</subject><subject>Chromosome aberrations</subject><subject>Cohort analysis</subject><subject>Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental law</subject><subject>Environmental legislation</subject><subject>Environmental policy</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Genotoxicity</subject><subject>Health policy</subject><subject>Health risks</subject><subject>Hydrocarbons</subject><subject>Investigations</subject><subject>Legislation</subject><subject>Outdoor air quality</subject><subject>Particulate matter</subject><subject>Poisson density functions</subject><subject>Pollutants</subject><subject>Pollution</subject><subject>Public health</subject><subject>Pyrene</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Sulfur dioxide</subject><subject>Threshold limits</subject><subject>Urban areas</subject><subject>Water pollution effects</subject><issn>2190-4707</issn><issn>2190-4715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UclqHDEQbUIMMbZ_IKcCnzvR0qsvwQxjxzAmwcRnoZZKbhmN1JHUgfmbfGo0mZDcUpd6VL3l8KrqPSUfKB26j4kyTlhNGKkJ4S2r-ZvqnNGR1E1P27d_MenfVVcpvZIyLRv6pj2vfj5hWl1OYGLYQ54RtmsMC0oPz94GD4-3X7cbsXu424IKc4gZUl71AcpL2ghLcG7NR6L0GtRcXEIKe-lAy718QbC-XK3TEf0NyIiwrJOzCmaULs9HvVUWE6TVmCPy2R1giSGjyvYHfrqszox0Ca_-7Ivq-W77bfO53n25f9jc7mrVsC7XXac7bdppMFoZM_TDxDhTSiKTw9SjVqQhvWKtGTX2vSZGMt1oo8ZJo6QD8ovq-uRbsr-vmLJ4DWv0JVIwPo4dJx0dCoudWCqGlCIasUS7l_EgKBHHMsSpDFHKEL_LELyI-EmUCtm_YPxn_R_VL8nOkPw</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Ceretti, Elisabetta</creator><creator>Donato, Francesco</creator><creator>Zani, Claudia</creator><creator>Villarini, Milena</creator><creator>Verani, Marco</creator><creator>De Donno, Antonella</creator><creator>Bonetta, Sara</creator><creator>Feretti, Donatella</creator><creator>Carducci, Annalaura</creator><creator>Idolo, Adele</creator><creator>Carraro, Elisabetta</creator><creator>Covolo, Loredana</creator><creator>Moretti, Massimo</creator><creator>Palomba, Giacomo</creator><creator>Grassi, Tiziana</creator><creator>Bonetti, Alberto</creator><creator>Bonizzoni, Silvia</creator><creator>Biggeri, Annibale</creator><creator>Gelatti, Umberto</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><orcidid>https://orcid.org/0000-0002-4856-5364</orcidid></search><sort><creationdate>20201201</creationdate><title>Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?</title><author>Ceretti, Elisabetta ; Donato, Francesco ; Zani, Claudia ; Villarini, Milena ; Verani, Marco ; De Donno, Antonella ; Bonetta, Sara ; Feretti, Donatella ; Carducci, Annalaura ; Idolo, Adele ; Carraro, Elisabetta ; Covolo, Loredana ; Moretti, Massimo ; Palomba, Giacomo ; Grassi, Tiziana ; Bonetti, Alberto ; Bonizzoni, Silvia ; Biggeri, Annibale ; Gelatti, Umberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Air pollution</topic><topic>Air quality</topic><topic>Air quality assessments</topic><topic>Benzene</topic><topic>Benzo(a)pyrene</topic><topic>Biological effects</topic><topic>Biological properties</topic><topic>Biological samples</topic><topic>Biomarkers</topic><topic>Children</topic><topic>Chromosome aberrations</topic><topic>Cohort analysis</topic><topic>Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental law</topic><topic>Environmental legislation</topic><topic>Environmental policy</topic><topic>Epidemiology</topic><topic>Exposure</topic><topic>Genotoxicity</topic><topic>Health policy</topic><topic>Health risks</topic><topic>Hydrocarbons</topic><topic>Investigations</topic><topic>Legislation</topic><topic>Outdoor air quality</topic><topic>Particulate matter</topic><topic>Poisson density functions</topic><topic>Pollutants</topic><topic>Pollution</topic><topic>Public health</topic><topic>Pyrene</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Sulfur dioxide</topic><topic>Threshold limits</topic><topic>Urban areas</topic><topic>Water pollution effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceretti, Elisabetta</creatorcontrib><creatorcontrib>Donato, Francesco</creatorcontrib><creatorcontrib>Zani, Claudia</creatorcontrib><creatorcontrib>Villarini, Milena</creatorcontrib><creatorcontrib>Verani, Marco</creatorcontrib><creatorcontrib>De Donno, Antonella</creatorcontrib><creatorcontrib>Bonetta, Sara</creatorcontrib><creatorcontrib>Feretti, Donatella</creatorcontrib><creatorcontrib>Carducci, Annalaura</creatorcontrib><creatorcontrib>Idolo, Adele</creatorcontrib><creatorcontrib>Carraro, Elisabetta</creatorcontrib><creatorcontrib>Covolo, Loredana</creatorcontrib><creatorcontrib>Moretti, Massimo</creatorcontrib><creatorcontrib>Palomba, Giacomo</creatorcontrib><creatorcontrib>Grassi, Tiziana</creatorcontrib><creatorcontrib>Bonetti, Alberto</creatorcontrib><creatorcontrib>Bonizzoni, Silvia</creatorcontrib><creatorcontrib>Biggeri, Annibale</creatorcontrib><creatorcontrib>Gelatti, Umberto</creatorcontrib><creatorcontrib>MAPEC_LIFE Study Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environmental Science Collection</collection><jtitle>Environmental sciences Europe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceretti, Elisabetta</au><au>Donato, Francesco</au><au>Zani, Claudia</au><au>Villarini, Milena</au><au>Verani, Marco</au><au>De Donno, Antonella</au><au>Bonetta, Sara</au><au>Feretti, Donatella</au><au>Carducci, Annalaura</au><au>Idolo, Adele</au><au>Carraro, Elisabetta</au><au>Covolo, Loredana</au><au>Moretti, Massimo</au><au>Palomba, Giacomo</au><au>Grassi, Tiziana</au><au>Bonetti, Alberto</au><au>Bonizzoni, Silvia</au><au>Biggeri, Annibale</au><au>Gelatti, Umberto</au><aucorp>MAPEC_LIFE Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective?</atitle><jtitle>Environmental sciences Europe</jtitle><stitle>Environ Sci Eur</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>32</volume><issue>1</issue><artnum>74</artnum><issn>2190-4707</issn><eissn>2190-4715</eissn><abstract>Background
Children are at high risk of suffering health consequences of air pollution and childhood exposure can increase the risk of developing chronic diseases in adulthood. This study, part of the MAPEC_LIFE project (LIFE12 ENV/IT/000614), aimed to investigate the associations between exposure to urban air pollutants and micronucleus (MN) frequency, as a biomarker of chromosomal damage, in buccal cells of children for supporting implementation and updating of environmental policy and legislation.
Methods
This prospective epidemiological cohort study was carried out on 6- to 8-year-old children living in five Italian towns with different levels and features of air pollution. Exfoliated buccal cells of the children were sampled twice, in winter and spring, obtaining 2139 biological samples for genotoxicological investigation. Micronucleus (MN) frequency was investigated in buccal cells of children and its association with air pollution exposure was assessed applying multiple Poisson regression mixed models, including socio-demographic and lifestyle factors as confounders. We also dichotomize air pollutants’ concentration according to the EU Ambient Air Quality Directives and WHO Air Quality Guidelines in all Poisson regression models to assess their risk predictive capacity.
Results
Positive and statistically significant associations were found between MN frequency and PM10, PM2.5, benzene, SO
2
and ozone. The increment of the risk of having MN in buccal cells for each μg/m
3
increase of pollutant concentration was maximum for benzene (18.9%, 95% CIs 2.2–38.4%) and modest for the other pollutants (between 0.2 and 1.4%). An increased risk (between 17.9% and 59.8%) was found also for exposure to PM10, benzene and benzo(a)pyrene levels higher than the threshold limits.
Conclusions
Some air pollutants are able to induce chromosomal damage in buccal cells of children even at concentrations below present EU/WHO limits. This type of biological effects may be indicative of the environmental pressure which populations are exposed to in urban areas.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s12302-020-00352-3</doi><orcidid>https://orcid.org/0000-0002-4856-5364</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2190-4707 |
ispartof | Environmental sciences Europe, 2020-12, Vol.32 (1), Article 74 |
issn | 2190-4707 2190-4715 |
language | eng |
recordid | cdi_proquest_journals_2399630618 |
source | Springer Nature - SpringerLink Journals - Fully Open Access |
subjects | Air pollution Air quality Air quality assessments Benzene Benzo(a)pyrene Biological effects Biological properties Biological samples Biomarkers Children Chromosome aberrations Cohort analysis Damage Earth and Environmental Science Ecotoxicology Environment Environmental law Environmental legislation Environmental policy Epidemiology Exposure Genotoxicity Health policy Health risks Hydrocarbons Investigations Legislation Outdoor air quality Particulate matter Poisson density functions Pollutants Pollution Public health Pyrene Regression analysis Regression models Statistical analysis Statistical methods Sulfur dioxide Threshold limits Urban areas Water pollution effects |
title | Results from the European Union MAPEC_LIFE cohort study on air pollution and chromosomal damage in children: are public health policies sufficiently protective? |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A34%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Results%20from%20the%20European%20Union%20MAPEC_LIFE%20cohort%20study%20on%20air%20pollution%20and%20chromosomal%20damage%20in%20children:%20are%20public%20health%20policies%20sufficiently%20protective?&rft.jtitle=Environmental%20sciences%20Europe&rft.au=Ceretti,%20Elisabetta&rft.aucorp=MAPEC_LIFE%20Study%20Group&rft.date=2020-12-01&rft.volume=32&rft.issue=1&rft.artnum=74&rft.issn=2190-4707&rft.eissn=2190-4715&rft_id=info:doi/10.1186/s12302-020-00352-3&rft_dat=%3Cproquest_cross%3E2399630618%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c426t-66d6df5b8fdcff878b232ccae2a8b7edc0407c25f9de77d0fa2d4dfc9bdea18e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2399630618&rft_id=info:pmid/&rfr_iscdi=true |