Effect of lacritin, a novel glycoprotein, on ocular surface and tear film integrity

Purpose Dry eye is extremely common and debilitating. Treatment options are palliative at best and do not address the underlying pathology. Lacritin, a newly discovered glycoprotein, is secreted naturally in human tears by the lacrimal gland. Human recombinant lacritin stimulated tear secretion in n...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2011-09, Vol.89 (s248), p.0-0
Main Authors: SAMUDRE, S, LATTANZIO, F, WILLIAMS, P, MCKOWN, R, LAURIE, G
Format: Article
Language:English
Subjects:
Cell density
Cyclosporins
Cytology
Glycoproteins
Inflammation
Lacrimal gland and Nasolacrimal duct
Tears
Topical application
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Summary:Purpose Dry eye is extremely common and debilitating. Treatment options are palliative at best and do not address the underlying pathology. Lacritin, a newly discovered glycoprotein, is secreted naturally in human tears by the lacrimal gland. Human recombinant lacritin stimulated tear secretion in normal rabbits and is well tolerated, leading us to hypothesize that topical application of lacritin will not adversely affect ocular surface and tear film integrity. Methods We compared full length lacritin construct with cyclosporin (Restasis®), in terms of tear break up time (TBUT) and goblet cell density using impression cytology. Lacritin (10, 50 μg/ml), or cyclosporin (0.05%), were administered bilaterally to New Zealand white rabbits three times daily for 14d (n=4/group). Results TBUT after lacritin (10 or 50 μg/ml) treatment was 12±2sec, which was similar to vehicle alone, but significantly decreased after cyclosporine treatment for 14d (6±3sec, p
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2011.460.x