Cholesterol-functionalized carvedilol-loaded PLGA nanoparticles: anti-inflammatory, antioxidant, and antitumor effects

The inflammation has been identified as factor of tumor progression, which has increased the interest and use of molecules with anti-inflammatory and antioxidant activities in the cancer treatment. In this study, the antioxidant, anti-inflammatory, and antitumor potentials of carvedilol was explored...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2020-05, Vol.22 (5), Article 115
Main Authors: de S. L. Oliveira, Ana Luiza C., dos Santos-Silva, Alaine M., da Silva-Júnior, Arnóbio A., Garcia, Vinícius B., de Araújo, Aurigena A., de Geus-Oei, Lioe-Fee, Chan, Alan B., Cruz, Luis J., de Araújo Júnior, Raimundo F.
Format: Article
Language:English
Subjects:
Anticancer properties
Antioxidants
Antitumor activity
Apoptosis
Cancer
Cell viability
Characterization and Evaluation of Materials
Chemistry and Materials Science
Cholesterol
Colorectal carcinoma
Copolymers
Flow cytometry
Glutathione
Inflammation
Inorganic Chemistry
Lasers
Leukocyte migration
Leukocytes
Materials Science
Nanoparticles
Nanotechnology
Optical Devices
Optics
Oxidative stress
Peritonitis
Photonics
Physical Chemistry
Polylactide-co-glycolide
Research Paper
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The inflammation has been identified as factor of tumor progression, which has increased the interest and use of molecules with anti-inflammatory and antioxidant activities in the cancer treatment. In this study, the antioxidant, anti-inflammatory, and antitumor potentials of carvedilol was explored in a different approach. The cholesterol (CHO) was investigated as facilitated agent in the action of carvedilol-loaded nanoparticles. Different formulations exhibited spherical and stable nanoparticle with mean diameter size
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-020-04832-8