Twenty-five years of polymersomes: lost in translation?

Soon after the discovery of polymeric vesicles (polymersomes), reports of their high membrane stability raised hopes for the development of next generation vesicles for drug delivery and diagnostic applications. Twenty-five years later, however, liposomes remain the only clinically tested colloidal...

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Bibliographic Details
Published in:Materials horizons 2020-01, Vol.7 (5), p.1297-139
Main Authors: Matoori, Simon, Leroux, Jean-Christophe
Format: Article
Language:English
Subjects:
Diagnostic software
Diagnostic systems
Drug delivery systems
Liposomes
Pharmacology
Vesicles
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Summary:Soon after the discovery of polymeric vesicles (polymersomes), reports of their high membrane stability raised hopes for the development of next generation vesicles for drug delivery and diagnostic applications. Twenty-five years later, however, liposomes remain the only clinically tested colloidal vesicular formulations. To highlight the translational challenges faced by polymersomes, we critically reviewed a selection of polymersome formulations with a focus on their pharmacokinetic and pharmacodynamic aspects. In this minireview, we discuss the progress of polymersome formulations towards clinical translation and highlight key opportunities and challenges.
ISSN:2051-6347
2051-6355
DOI:10.1039/c9mh01669d