Synthesis of Isoindolinones through Intramolecular Amidation of ortho‐Vinyl Benzamides

A synthetic approach of isoindolinones through intramolecular amidation of ortho‐vinyl benzamides was reported. A variety of N‐aryl isoindolinone derivatives were prepared in moderate to excellent yields using perfluorobutyl iodide as oxidant.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-05, Vol.362 (10), p.1972-1976
Main Authors: Wei, Wen‐tao, Chen, Zhen‐yu, Lin, Yong‐lu, Chen, Ri‐xing, Wang, Qi, Wu, Qing‐guang, Liu, Si‐jun, Yan, Ming, Zhang, Xue‐jing
Format: Article
Language:English
Subjects:
Aromatic compounds
intramolecular amidation
isoindolinones
ortho-vinyl benzamides
Oxidizing agents
perfluorobutyl iodide
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Description
Summary:A synthetic approach of isoindolinones through intramolecular amidation of ortho‐vinyl benzamides was reported. A variety of N‐aryl isoindolinone derivatives were prepared in moderate to excellent yields using perfluorobutyl iodide as oxidant.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000260