Molecular Docking analysis of the TNIK Receptor protein with a potential Inhibitor from the NPACT database

It is of interest to design and develop efficient inhibitors to the TNIK protein target in Wnt signaling pathways in the context of colorectal cancer (CRC) using molecular docking models. We show data to support that a compound named aglafoline (methyl (1R,2R,3S,3aR,8bS)1,8b-dihydroxy-6,8-dimethoxy-...

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Bibliographic Details
Published in:Bioinformation 2020-05, Vol.16 (5), p.387
Main Authors: Rosita, Arokiaraj Sherlin, Begum, Tajuddin Nargis
Format: Article
Language:English
Subjects:
Anticancer properties
Colorectal carcinoma
Context
Data bases
Molecular docking
Molecular modelling
Proteins
Receptors
Wnt protein
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Summary:It is of interest to design and develop efficient inhibitors to the TNIK protein target in Wnt signaling pathways in the context of colorectal cancer (CRC) using molecular docking models. We show data to support that a compound named aglafoline (methyl (1R,2R,3S,3aR,8bS)1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H cyclopenta [b] [1] from the NPACT (Naturally Occurring Plant-based Anti-cancer Compound-Activity-Target database) database have optimal binding features with the TNIK receptor for further consideration in this context.
ISSN:0973-8894
0973-2063
DOI:10.6026/97320630016351