Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells

Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2020-06, Vol.29 (6), p.935-941
Main Authors: Patel, Hinal, Mothia, Begum, Patel, Jaison, Fasanya, Olatunde, Sooda, Kartheek, Javid, Farideh, Wyatt, Peter B.
Format: Article
Language:English
Subjects:
Aldehydes
Aliphatic compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cisplatin
Cytotoxicity
Hydroxybenzaldehydes
Ketones
Original Research
Ovarian cancer
Ovarian carcinoma
Pharmacology/Toxicology
Toxicity
Vanillin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653
cites cdi_FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653
container_end_page 941
container_issue 6
container_start_page 935
container_title Medicinal chemistry research
container_volume 29
creator Patel, Hinal
Mothia, Begum
Patel, Jaison
Fasanya, Olatunde
Sooda, Kartheek
Javid, Farideh
Wyatt, Peter B.
description Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.
doi_str_mv 10.1007/s00044-020-02532-5
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2401930506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2401930506</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653</originalsourceid><addsrcrecordid>eNp9kMtKBDEQRRtR8PkDrgJudNFaeXXPLGXwBYIbXYd0ktZoTzKmMqP9Af63GUdw56Koojh1C05VHVM4pwDtBQKAEDUwKCU5q-VWtUelFPWEMtguM5SZScZ3q33EVwDegpB71ddszDHHT298HknsCca5IziG_OKyN6TzeKrTOHjrgjsj1iW_0tmvHK5hM5qhQG8ux1A2OX7oZJEYj4uhUKFODj1mHTJ5Wc51IHGlky_d6GR8iHNNjBsGPKx2ej2gO_rtB9XT9dXj7La-f7i5m13e14Y3PNeWA20M7YSdCGs0b62UVjdsatte9JwZrTVM-7ZrjezMFLrWNZpOtHFWNLaR_KA62eQuUnxfOszqNS5TKC8VE0CnHCQ0hWIbyqSImFyvFsnPiwVFQa11q41uVXSrH91qHc03R1jg8OzSX_Q_V9-Jnob_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2401930506</pqid></control><display><type>article</type><title>Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells</title><source>Springer Link</source><creator>Patel, Hinal ; Mothia, Begum ; Patel, Jaison ; Fasanya, Olatunde ; Sooda, Kartheek ; Javid, Farideh ; Wyatt, Peter B.</creator><creatorcontrib>Patel, Hinal ; Mothia, Begum ; Patel, Jaison ; Fasanya, Olatunde ; Sooda, Kartheek ; Javid, Farideh ; Wyatt, Peter B.</creatorcontrib><description>Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-020-02532-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aldehydes ; Aliphatic compounds ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cell Biology ; Cisplatin ; Cytotoxicity ; Hydroxybenzaldehydes ; Ketones ; Original Research ; Ovarian cancer ; Ovarian carcinoma ; Pharmacology/Toxicology ; Toxicity ; Vanillin</subject><ispartof>Medicinal chemistry research, 2020-06, Vol.29 (6), p.935-941</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653</citedby><cites>FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Patel, Hinal</creatorcontrib><creatorcontrib>Mothia, Begum</creatorcontrib><creatorcontrib>Patel, Jaison</creatorcontrib><creatorcontrib>Fasanya, Olatunde</creatorcontrib><creatorcontrib>Sooda, Kartheek</creatorcontrib><creatorcontrib>Javid, Farideh</creatorcontrib><creatorcontrib>Wyatt, Peter B.</creatorcontrib><title>Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.</description><subject>Aldehydes</subject><subject>Aliphatic compounds</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cisplatin</subject><subject>Cytotoxicity</subject><subject>Hydroxybenzaldehydes</subject><subject>Ketones</subject><subject>Original Research</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Pharmacology/Toxicology</subject><subject>Toxicity</subject><subject>Vanillin</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKBDEQRRtR8PkDrgJudNFaeXXPLGXwBYIbXYd0ktZoTzKmMqP9Af63GUdw56Koojh1C05VHVM4pwDtBQKAEDUwKCU5q-VWtUelFPWEMtguM5SZScZ3q33EVwDegpB71ddszDHHT298HknsCca5IziG_OKyN6TzeKrTOHjrgjsj1iW_0tmvHK5hM5qhQG8ux1A2OX7oZJEYj4uhUKFODj1mHTJ5Wc51IHGlky_d6GR8iHNNjBsGPKx2ej2gO_rtB9XT9dXj7La-f7i5m13e14Y3PNeWA20M7YSdCGs0b62UVjdsatte9JwZrTVM-7ZrjezMFLrWNZpOtHFWNLaR_KA62eQuUnxfOszqNS5TKC8VE0CnHCQ0hWIbyqSImFyvFsnPiwVFQa11q41uVXSrH91qHc03R1jg8OzSX_Q_V9-Jnob_</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Patel, Hinal</creator><creator>Mothia, Begum</creator><creator>Patel, Jaison</creator><creator>Fasanya, Olatunde</creator><creator>Sooda, Kartheek</creator><creator>Javid, Farideh</creator><creator>Wyatt, Peter B.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20200601</creationdate><title>Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells</title><author>Patel, Hinal ; Mothia, Begum ; Patel, Jaison ; Fasanya, Olatunde ; Sooda, Kartheek ; Javid, Farideh ; Wyatt, Peter B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aldehydes</topic><topic>Aliphatic compounds</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cisplatin</topic><topic>Cytotoxicity</topic><topic>Hydroxybenzaldehydes</topic><topic>Ketones</topic><topic>Original Research</topic><topic>Ovarian cancer</topic><topic>Ovarian carcinoma</topic><topic>Pharmacology/Toxicology</topic><topic>Toxicity</topic><topic>Vanillin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Hinal</creatorcontrib><creatorcontrib>Mothia, Begum</creatorcontrib><creatorcontrib>Patel, Jaison</creatorcontrib><creatorcontrib>Fasanya, Olatunde</creatorcontrib><creatorcontrib>Sooda, Kartheek</creatorcontrib><creatorcontrib>Javid, Farideh</creatorcontrib><creatorcontrib>Wyatt, Peter B.</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Hinal</au><au>Mothia, Begum</au><au>Patel, Jaison</au><au>Fasanya, Olatunde</au><au>Sooda, Kartheek</au><au>Javid, Farideh</au><au>Wyatt, Peter B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2020-06-01</date><risdate>2020</risdate><volume>29</volume><issue>6</issue><spage>935</spage><epage>941</epage><pages>935-941</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>Symmetrical α,αʹ-bis(arylidene)ketones were prepared by acid-catalyzed aldol condensations between aliphatic ketones (e.g., cyclopentanone, 4-alkylcyclohexanones, tetrahydropyran-4-one, and tetrahydrothiopyran-4-one) and two equivalents of an aromatic hydroxyaldehyde (e.g., 4-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, vanillin, isovanillin, and 3-fluoro-4-hydroxybenzaldehyde). Most of the compounds were cytotoxic towards the cisplatin-resistant human ovarian cancer cell line A2780-CP70 as well as the non-resistant line A2780.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s00044-020-02532-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1054-2523
ispartof Medicinal chemistry research, 2020-06, Vol.29 (6), p.935-941
issn 1054-2523
1554-8120
language eng
recordid cdi_proquest_journals_2401930506
source Springer Link
subjects Aldehydes
Aliphatic compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Biology
Cisplatin
Cytotoxicity
Hydroxybenzaldehydes
Ketones
Original Research
Ovarian cancer
Ovarian carcinoma
Pharmacology/Toxicology
Toxicity
Vanillin
title Cytotoxicity of some synthetic bis(arylidene) derivatives of cyclic ketones towards cisplatin-resistant human ovarian carcinoma cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A35%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytotoxicity%20of%20some%20synthetic%20bis(arylidene)%20derivatives%20of%20cyclic%20ketones%20towards%20cisplatin-resistant%20human%20ovarian%20carcinoma%20cells&rft.jtitle=Medicinal%20chemistry%20research&rft.au=Patel,%20Hinal&rft.date=2020-06-01&rft.volume=29&rft.issue=6&rft.spage=935&rft.epage=941&rft.pages=935-941&rft.issn=1054-2523&rft.eissn=1554-8120&rft_id=info:doi/10.1007/s00044-020-02532-5&rft_dat=%3Cproquest_cross%3E2401930506%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c363t-d3016c1b4d84dca37d55da629d7f4f32caaa09f7b7c5bc90b7e6a18aced46d653%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2401930506&rft_id=info:pmid/&rfr_iscdi=true