Study on cytotoxicity of polyethylene glycol and albumin bovine serum molecule–modified quantum dots prepared by hydrothermal method

Fluorescent quantum dots (QDs) modified with polyethylene glycol (PEG) and albumin bovine serum (BSA) have profound application in the detection and treatment of hepatocellular carcinoma (HCC) cells. In the present study, the effects and mechanism of PEG and BSA modification on the cytotoxicity of Q...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials research 2020-05, Vol.35 (9), p.1135-1142
Main Authors: Hong, Enlv, Liu, Lumin, Li, Chen, Shan, Dan, Cao, Hailong, Wang, Baiqi
Format: Article
Language:English
Subjects:
Albumins
Applied and Technical Physics
Biomaterials
Biomedical Materials
Cytotoxicity
Fluorescence
Inorganic Chemistry
Liver cancer
Materials Engineering
Materials research
Materials Science
Medical prognosis
Methods
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Particle size
Polyethylene glycol
Quantum dots
Regenerative Medicine and Drug Delivery
Stem cells
Superoxide dismutase
Time dependence
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fluorescent quantum dots (QDs) modified with polyethylene glycol (PEG) and albumin bovine serum (BSA) have profound application in the detection and treatment of hepatocellular carcinoma (HCC) cells. In the present study, the effects and mechanism of PEG and BSA modification on the cytotoxicity of QDs have been explored. It was found that the diameter of the as-prepared QDs, PEG@QDs, BSA@QDs is 3–5 nm, 4–5 nm, and 4–6 nm, respectively. With increase of the treatment time from 0 to 24 h, the HCC cell viability treated with QDs, PEG@QDs, and BSA@QDs obviously decreases, showing a certain time-dependent manner. When the concentration of several nanomaterials is increased from 10 to 90 nM, the cell viability decreases accordingly, exhibiting a certain concentration-dependent manner. Under the same concentration change conditions, the reactive oxygen species contents of cells treated by QDs, PEG@QDs, and BSA@QDs also rise from 7.9 × 10 3 , 6.7 × 10 3 , and 4.7 × 10 3 to 13.2 × 10 3 , 14.3 × 10 3 , and 12.3 × 10 3 , respectively. In these processes, superoxide dismutase does not play a major role. This study provides strong foundation and useful guidance for QD applications in the diagnosis and treatment of HCC.
ISSN:0884-2914
2044-5326
DOI:10.1557/jmr.2020.78