Current and research therapies for the prevention and treatment of delayed neurological syndrome associated with carbon monoxide poisoning: A narrative review

Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless...

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Bibliographic Details
Published in:Human & Experimental Toxicology 2020-06, Vol.39 (6), p.765-772
Main Authors: del Moral-Barbudo, B, Blancas, R, Ballesteros-Ortega, D, Quintana-Díaz, M, Martínez-González, Ó
Format: Article
Language:English
Subjects:
Animals
Carbon monoxide
Carbon monoxide poisoning
Carbon Monoxide Poisoning - complications
Carbon Monoxide Poisoning - drug therapy
Carbon Monoxide Poisoning - therapy
Humans
Hyperbaric oxygen
Inhalation
Neurological complications
Neurotoxicity Syndromes - etiology
Neurotoxicity Syndromes - prevention & control
Oxygen Inhalation Therapy
Poisoning
Prevention
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Summary:Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains controversial due to the lack of evidence regarding its efficacy. The aim of this review is to report therapies under investigation for preventing or improving DNS, some of them with promising results in humans.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327120901572