Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle

Protein degradation by the ubiquitin-proteasome system (UPS) is essential for life. Degradation of enzymes and other regulatory proteins like activators or inhibitors is crucial for a multitude of cellular processes. Prominent examples are cell cycle progression or regulation of metabolic pathways....

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Bibliographic Details
Published in:Biospektrum 2015-10, Vol.21 (6), p.608-611
Main Authors: Menssen, Ruth, Wolf, Dieter H.
Format: Article
Language:ger
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell cycle
Human Genetics
Life Sciences
Metabolic pathways
Microbiology
Pharmacology/Toxicology
Proteasomes
Protein folding
Regulatory proteins
Ubiquitin
Wissenschaft
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Summary:Protein degradation by the ubiquitin-proteasome system (UPS) is essential for life. Degradation of enzymes and other regulatory proteins like activators or inhibitors is crucial for a multitude of cellular processes. Prominent examples are cell cycle progression or regulation of metabolic pathways. Furthermore, elimination of misfolded proteins is essential to prevent disturbance of cell functions.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-015-0621-8