Malatproduktion aus Rohglycerin mit Ustilago

The use of biodiesel derived crude glycerol for the production of value added chemicals has been discussed frequently. Current glycerol-based microbial production process often suffers from low rates, titers, and yields, hindering their industrial application. Here we report on the identification an...

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Bibliographic Details
Published in:Biospektrum 2018-03, Vol.24 (2), p.218-220
Main Authors: Zambanini, Thiemo, Gauert, Marc, Meurer, Guido, Wierckx, Nick, Blank, Lars M.
Format: Article
Language:English
Subjects:
Biochemistry
Biofuels
Biomedical and Life Sciences
Biotechnologie
Glycerol
Human Genetics
Industrial applications
Life Sciences
Malic acid
Metabolic engineering
Microbiology
Pharmacology/Toxicology
Ustilago
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Summary:The use of biodiesel derived crude glycerol for the production of value added chemicals has been discussed frequently. Current glycerol-based microbial production process often suffers from low rates, titers, and yields, hindering their industrial application. Here we report on the identification and optimization of Ustilago trichophora as promising novel production organism for malic acid from glycerol. All optimization steps presented avoid metabolic engineering resulting in a non-GMO organism.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-018-0908-7