Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease

Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H 2 W 12 O 42 ] 10− and [TeW 6 O 24 ] 6− ha...

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Bibliographic Details
Published in:Medicinal chemistry research 2013-03, Vol.22 (3), p.1224-1228
Main Authors: Iqbal, Jamshed, Barsukova-Stuckart, Maria, Ibrahim, Masooma, Ali, Syed Usman, Khan, Aftab Ahmed, Kortz, Ulrich
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Alzheimer's disease
Anticancer properties
Antiviral activity
Antiviral agents
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cholinesterase
Cholinesterase inhibitors
Inhibitors
Neurodegenerative diseases
Original Research
Pharmacology/Toxicology
Polyoxometallates
Selectivity
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Summary:Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H 2 W 12 O 42 ] 10− and [TeW 6 O 24 ] 6− have the most potent acetylcholinesterase activity, exhibiting IC 50 values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O 3 PCH 2 PO 3 ) 4 W 12 O 36 ] 16− was a potent and selective inhibitor of butyrylcholinesterase with IC 50 value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0125-8