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Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease
Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H 2 W 12 O 42 ] 10− and [TeW 6 O 24 ] 6− ha...
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| Published in: | Medicinal chemistry research 2013-03, Vol.22 (3), p.1224-1228 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c359t-844e9d3b3074ed6b63188d53ede7f5a3d8dc0bf458308ba7b2e92634c9727d813 |
| container_end_page | 1228 |
| container_issue | 3 |
| container_start_page | 1224 |
| container_title | Medicinal chemistry research |
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| creator | Iqbal, Jamshed Barsukova-Stuckart, Maria Ibrahim, Masooma Ali, Syed Usman Khan, Aftab Ahmed Kortz, Ulrich |
| description | Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H
2
W
12
O
42
]
10−
and [TeW
6
O
24
]
6−
have the most potent acetylcholinesterase activity, exhibiting IC
50
values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O
3
PCH
2
PO
3
)
4
W
12
O
36
]
16−
was a potent and selective inhibitor of butyrylcholinesterase with IC
50
value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors. |
| doi_str_mv | 10.1007/s00044-012-0125-8 |
| format | article |
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2
W
12
O
42
]
10−
and [TeW
6
O
24
]
6−
have the most potent acetylcholinesterase activity, exhibiting IC
50
values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O
3
PCH
2
PO
3
)
4
W
12
O
36
]
16−
was a potent and selective inhibitor of butyrylcholinesterase with IC
50
value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-012-0125-8</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Acetylcholinesterase ; Alzheimer's disease ; Anticancer properties ; Antiviral activity ; Antiviral agents ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cholinesterase ; Cholinesterase inhibitors ; Inhibitors ; Neurodegenerative diseases ; Original Research ; Pharmacology/Toxicology ; Polyoxometallates ; Selectivity</subject><ispartof>Medicinal chemistry research, 2013-03, Vol.22 (3), p.1224-1228</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media, LLC 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-844e9d3b3074ed6b63188d53ede7f5a3d8dc0bf458308ba7b2e92634c9727d813</citedby><cites>FETCH-LOGICAL-c359t-844e9d3b3074ed6b63188d53ede7f5a3d8dc0bf458308ba7b2e92634c9727d813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Iqbal, Jamshed</creatorcontrib><creatorcontrib>Barsukova-Stuckart, Maria</creatorcontrib><creatorcontrib>Ibrahim, Masooma</creatorcontrib><creatorcontrib>Ali, Syed Usman</creatorcontrib><creatorcontrib>Khan, Aftab Ahmed</creatorcontrib><creatorcontrib>Kortz, Ulrich</creatorcontrib><title>Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H
2
W
12
O
42
]
10−
and [TeW
6
O
24
]
6−
have the most potent acetylcholinesterase activity, exhibiting IC
50
values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O
3
PCH
2
PO
3
)
4
W
12
O
36
]
16−
was a potent and selective inhibitor of butyrylcholinesterase with IC
50
value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors.</description><subject>Acetylcholinesterase</subject><subject>Alzheimer's disease</subject><subject>Anticancer properties</subject><subject>Antiviral activity</subject><subject>Antiviral agents</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cholinesterase</subject><subject>Cholinesterase inhibitors</subject><subject>Inhibitors</subject><subject>Neurodegenerative diseases</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Polyoxometallates</subject><subject>Selectivity</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kM9Kw0AQxoMoWKsP4G3Bc3T2X7M5luI_KOhBz2GTnbQpabbubsF48gV8AF_PJ3FDRE8ehhmY7_cN8yXJOYVLCpBdeQAQIgXKhpKpOkgmVEqRKsrgMM4QZyYZP05OvN8A8AyEnCQfj7bt7avdYtCtDuiJ9mRnA3aBNN26KZtgnSe1dURXGPqW6M6Qch9617fV2rZNhz6g035A4-oXb3RLjNuvRjiskQSHOmwHZ1uTefu2xmaL7uv90xPTeIwWp8lRrVuPZz99mjzfXD8t7tLlw-39Yr5MKy7zkCohMDe85JAJNLNyxqlSRnI0mNVSc6NMBWUtpOKgSp2VDHM246LKM5YZRfk0uRh9d86-7OMDxcbuXRdPFkyA4PkMQEYVHVWVs947rIuda7ba9QWFYki9GFMvYuJDyUJFho2Mj9puhe7P-X_oG3LaiTU</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Iqbal, Jamshed</creator><creator>Barsukova-Stuckart, Maria</creator><creator>Ibrahim, Masooma</creator><creator>Ali, Syed Usman</creator><creator>Khan, Aftab Ahmed</creator><creator>Kortz, Ulrich</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>20130301</creationdate><title>Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease</title><author>Iqbal, Jamshed ; Barsukova-Stuckart, Maria ; Ibrahim, Masooma ; Ali, Syed Usman ; Khan, Aftab Ahmed ; Kortz, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-844e9d3b3074ed6b63188d53ede7f5a3d8dc0bf458308ba7b2e92634c9727d813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcholinesterase</topic><topic>Alzheimer's disease</topic><topic>Anticancer properties</topic><topic>Antiviral activity</topic><topic>Antiviral agents</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cholinesterase</topic><topic>Cholinesterase inhibitors</topic><topic>Inhibitors</topic><topic>Neurodegenerative diseases</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Polyoxometallates</topic><topic>Selectivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iqbal, Jamshed</creatorcontrib><creatorcontrib>Barsukova-Stuckart, Maria</creatorcontrib><creatorcontrib>Ibrahim, Masooma</creatorcontrib><creatorcontrib>Ali, Syed Usman</creatorcontrib><creatorcontrib>Khan, Aftab Ahmed</creatorcontrib><creatorcontrib>Kortz, Ulrich</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iqbal, Jamshed</au><au>Barsukova-Stuckart, Maria</au><au>Ibrahim, Masooma</au><au>Ali, Syed Usman</au><au>Khan, Aftab Ahmed</au><au>Kortz, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2013-03-01</date><risdate>2013</risdate><volume>22</volume><issue>3</issue><spage>1224</spage><epage>1228</epage><pages>1224-1228</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>Polyoxometalates (POMs) show significant importance in medicine due to their enzyme inhibition, antiviral and anticancer properties. In this study, some polyoxotungstates were identified as potent inhibitors of acetyl and butyrylcholinesterases. Compounds [H
2
W
12
O
42
]
10−
and [TeW
6
O
24
]
6−
have the most potent acetylcholinesterase activity, exhibiting IC
50
values of 0.29 ± 0.01 and 0.31 ± 0.01 μM, respectively. Whereas, compound [(O
3
PCH
2
PO
3
)
4
W
12
O
36
]
16−
was a potent and selective inhibitor of butyrylcholinesterase with IC
50
value of 0.18 ± 0.05 μM. In general, POMs were found to be effective cholinesterase inhibitors in terms of efficiency as well as selectivity and represent non-classical cholinesterase inhibitors.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><doi>10.1007/s00044-012-0125-8</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1054-2523 |
| ispartof | Medicinal chemistry research, 2013-03, Vol.22 (3), p.1224-1228 |
| issn | 1054-2523 1554-8120 |
| language | eng |
| recordid | cdi_proquest_journals_2404396005 |
| source | Springer Nature |
| subjects | Acetylcholinesterase Alzheimer's disease Anticancer properties Antiviral activity Antiviral agents Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cholinesterase Cholinesterase inhibitors Inhibitors Neurodegenerative diseases Original Research Pharmacology/Toxicology Polyoxometallates Selectivity |
| title | Polyoxometalates as potent inhibitors for acetyl and butyrylcholinesterases and as potential drugs for the treatment of Alzheimer’s disease |
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