Zinc Levels and Birth Weight in Pregnant Women with Gestational Diabetes Mellitus: A Matched Cohort Study in China

Zinc (Zn) has been suggested to impact fetal growth. However, the effect may be complicated by gestational diabetes mellitus (GDM) due to its impact on fetal growth and placental transport. This study aims to investigate whether GDM modifies the association between Zn levels and birth weight. A coho...

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Published in:The journal of clinical endocrinology and metabolism 2020-07, Vol.105 (7), p.e2337-e2345
Main Authors: Luo, Jiajun, Wu, Weiwei, Zhang, Ping, Chen, Xi, Feng, Yongliang, Ma, Ning, Yang, Hailan, Wang, Ying, Li, Mei, Xie, Bingjie, Guo, Pengge, Liew, Zeyan, Deziel, Nicole C, Vasiliou, Vasilis, Shi, Xiaoming, Wang, Suping, Zhang, Yawei
Format: Article
Language:English
Subjects:
Adult
Birth weight
Birth Weight - physiology
Body Mass Index
China
Cohort analysis
Cord blood
Diabetes
Diabetes mellitus
Diabetes, Gestational - blood
Diet
Dietary intake
Female
Fetuses
Health risk assessment
Humans
Infant, Newborn
Male
Placenta
Pregnancy
Zinc - blood
Zinc - deficiency
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Summary:Zinc (Zn) has been suggested to impact fetal growth. However, the effect may be complicated by gestational diabetes mellitus (GDM) due to its impact on fetal growth and placental transport. This study aims to investigate whether GDM modifies the association between Zn levels and birth weight. A cohort matched by GDM was established in Taiyuan, China, between 2012 and 2016, including 752 women with GDM and 744 women without. Dietary Zn intake was assessed during pregnancy. Maternal blood (MB) and cord blood (CB) Zn levels were measured at birth. Birth weight was standardized as the z score and categorized as high (HBW, >4000 g) and low (LBW,
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgaa171