Tissue failure propagation as mediated by circulatory flow

Aging is driven by subcellular processes that are relatively well-understood. However the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here we experimentally and theoretically...

Full description

Saved in:
Bibliographic Details
Published in:arXiv.org 2020-05
Main Authors: Uppal, Gurdip, Bahcecioglu, Gokhan, Zorlutuna, Pinar, Dervis Can Vural
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aging is driven by subcellular processes that are relatively well-understood. However the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade to a macro-level catastrophe in a tissue or organs remain largely unexplored. Here we experimentally and theoretically study how cell failure propagates in a synthetic tissue in the presence of advective flow. We argue that cells secrete cooperative factors, thereby forming a network of interdependence governed by diffusion and flow, which fails with a propagating front parallel to advective circulation.
ISSN:2331-8422
DOI:10.48550/arxiv.2005.10746