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Hierarchical Self‐Assembled Photo‐Responsive Tubisomes from a Cyclic Peptide‐Bridged Amphiphilic Block Copolymer

Typically, the morphologies of the self‐assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarch...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-06, Vol.59 (23), p.8860-8863
Main Authors: Yang, Jie, Song, Ji‐Inn, Song, Qiao, Rho, Julia Y., Mansfield, Edward D. H., Hall, Stephen C. L., Sambrook, Megan, Huang, Feihe, Perrier, Sébastien
Format: Article
Language:English
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Summary:Typically, the morphologies of the self‐assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarchical self‐assembly of cyclic peptide‐bridged amphiphilic diblock copolymers. The capacity of obtained photo‐responsive tubisomes as potential drug carriers is evaluated. The supramolecular tubisomes pave an alternative way for fabricating polymeric tubular structures, and will expand the toolbox for the rational design of functional hierarchical nanostructures. Hierarchical supramolecular self‐assembly of a cyclic peptide functional amphiphilic diblock copolymer into photo‐responsive tubisomes in water was investigated. These tubisomes are employed as photo‐controlled drug delivery vehicles for anticancer drug Doxorubicin to achieve enhanced intracellular DOX release and improved anticancer activity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201916111