Elucidating Noncovalent Reaction Mechanisms: G‐Quartet as an Intermediate in G‐Quadruplex Assembly

In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G‐quadruplex formation...

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Bibliographic Details
Published in:Angewandte Chemie 2020-06, Vol.132 (23), p.9126-9131
Main Authors: Martín‐Arroyo, Miguel, Prado, Anselmo, Chamorro, Raquel, Bilbao, Nerea, González‐Rodríguez, David
Format: Article
Language:English
Subjects:
Chemistry
G-quadruplex
G-quartets
guanine self-assembly
noncovalent synthesis
Organic solvents
Reaction mechanisms
supramolecular chemistry
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Summary:In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G‐quadruplex formation in organic solvents. Our results support a reaction pathway in which the cation shifts the equilibrium towards a G‐quartet transient intermediate, which then acts as a template in the formation of the G‐quadruplex product. G4 on the floor: The unprecedented K+ G‐quartet has been detected as a transient intermediate along the course of G‐quadruplex self‐assembly following an approach that is reminiscent of classical covalent mechanistic studies.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201916261