Recent Advances in the Electrochemical Synthesis and Functionalization of Indole Derivatives

The chemists’ pursuit of the ideal synthesis and functionalization of indole derivatives has lasted over 150 years as their scaffolds have been widely found in natural products, pharmaceuticals, agrochemicals and organic materials. In this regard, the recent resurgence of adopting green and sustaina...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-05, Vol.362 (11), p.2102-2119
Main Authors: Yu, Yi, Zhong, Jun‐Song, Xu, Kai, Yuan, Yaofeng, Ye, Ke‐Yin
Format: Article
Language:English
Subjects:
Agrochemicals
catalysis
Chemists
Derivatives
Electrochemistry
green chemistry
indoles
Natural products
Organic materials
radicals
Reaction mechanisms
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Summary:The chemists’ pursuit of the ideal synthesis and functionalization of indole derivatives has lasted over 150 years as their scaffolds have been widely found in natural products, pharmaceuticals, agrochemicals and organic materials. In this regard, the recent resurgence of adopting green and sustainable electrochemistry in organic synthesis suggests that electrosynthesis is a promising strategy. Indeed, many new intriguing applications of synthesis and functionalization of indole derivatives by direct and redox‐mediated electrochemical means have been disclosed. In this review, we highlight the fundamental aspects, reaction scopes, synthetic applications and reaction mechanisms of the electrochemical synthesis and functionalization of indole derivatives.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201901520