Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration

Emerging studies have addressed the role of probiotics in inflammation modulation via modifying gut microbiota. Perturbed gut microbiota is recognized as a pivotal trigger in the pathogenesis of rheumatoid arthritis (RA), and manipulating gut microbiota at the early phase may be helpful to alleviate...

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Bibliographic Details
Published in:Food & function 2020-05, Vol.11 (5), p.4499-4511
Main Authors: Fan, Zhexin, Yang, Bo, Ross, R Paul, Stanton, Catherine, Shi, Guoxun, Zhao, Jianxin, Zhang, Hao, Chen, Wei
Format: Article
Language:English
Subjects:
Animals
Antibodies
Arthritis
Arthritis, Experimental - chemically induced
Arthritis, Experimental - drug therapy
Autoantibodies
Bifidobacterium adolescentis
Bifidobacterium adolescentis - metabolism
Collagen
Digestive system
Disease Models, Animal
Drug Administration Schedule
Dysbacteriosis
Fatty acids
Female
Gastrointestinal tract
Health services
Inflammation
Intestinal microflora
Intestine
Microbiota
Microorganisms
Pathogenesis
Probiotics
Probiotics - administration & dosage
Rats
Rats, Wistar
Rheumatoid arthritis
Signs and symptoms
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Summary:Emerging studies have addressed the role of probiotics in inflammation modulation via modifying gut microbiota. Perturbed gut microbiota is recognized as a pivotal trigger in the pathogenesis of rheumatoid arthritis (RA), and manipulating gut microbiota at the early phase may be helpful to alleviate the disease based on the fact that dysbiosis occurred prior to clinical arthritis. The current study compared the effects of preventive and therapeutic treatment with Bifidobacterium adolescentis on collagen induced arthritis (CIA) in rats. Early B. adolescentis administration before CIA modelling performed better than late B. adolescentis treatment in reducing the clinical symptoms, rebalancing the pro- and anti-inflammatory responses and maintaining the fecal concentration of short chain fatty acids (SCFAs), as well as restoring the intestinal dysbiosis. Preventive B. adolescentis treatment restored the gut microbiota to a normal level while late B. adolescentis fed rats showed clearly different gut microbial profiles. In addition, there were slight discrepancies between early- and late- treatment of B. adolescentis in the production of specific auto-antibodies and tight junction proteins. All those results highlighted that early treatment of probiotics in arthritis might be a better timing for alleviating arthritis.
ISSN:2042-6496
2042-650X
DOI:10.1039/d0fo00077a