Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanos...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (43), p.5747-575
Main Authors: Magdalena Estirado, Eva, Rosier, Bas J. H. M, de Greef, Tom F. A, Brunsveld, Luc
Format: Article
Language:English
Subjects:
Caspase 9 - chemistry
DNA - chemistry
Enzyme activity
Enzymes
Modularity
Nanostructures - chemistry
Polymers - chemistry
Pyridines - chemistry
Recruitment
Supramolecular polymers
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Summary:Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer. Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc02120b