Loading…
CAR T Cells for Solid Tumors
Purpose of Review In this manuscript, we review the current state of chimeric antigen receptor (CAR) T cells, their successes and shortcomings in targeting solid tumors. These engineered receptors have evolved from an over reaching concept to a clinical product that has revolutionized cancer therapy...
Saved in:
Published in: | Current stem cell reports 2017-12, Vol.3 (4), p.269-278 |
---|---|
Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Purpose of Review
In this manuscript, we review the current state of chimeric antigen receptor (CAR) T cells, their successes and shortcomings in targeting solid tumors. These engineered receptors have evolved from an over reaching concept to a clinical product that has revolutionized cancer therapy.
Recent Findings
Unlike earlier generations of expanded tumor-infiltrating lymphocytes, CAR T cells are not limited to an MHC-restricted response. Armed with multiple costimulatory domains in one frame, CAR T cells carry unparalleled activation potential. CAR T cells for relapsed leukemia have had an enormous impact on the field of cancer immunology and have become a beacon of hope for some difficult to treat patients. Unfortunately, CAR T cells have to date not shown similar efficacy for solid tumors.
Summary
Here, we delve into specifics within solid tumor microenvironments that are responsible for dampening CAR T cell efficacy. Each of these elements constitutes a front where future opportunity lies. We encourage our readers to explore this field, which is in its infancy, and take steps to move it forward. |
---|---|
ISSN: | 2198-7866 2198-7866 |
DOI: | 10.1007/s40778-017-0101-9 |