Notch Signaling in Cell–Cell Communication Pathways

The Notch signaling pathway is a well-conserved molecular mechanism that serves the purpose of coordinating cellular events occurring within a group of neighboring cells. The interplay between ligands and receptors of the Notch family is crucial in determining Notch status and the outcome of any spe...

Full description

Saved in:
Bibliographic Details
Published in:Current stem cell reports 2016-12, Vol.2 (4), p.349-355
Main Authors: Bigas, Anna, Espinosa, Lluis
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cell Biology
Cell fate
Cell interactions
Gene Therapy
Homeostasis
Immunology
Life Sciences
Regenerative medicine
Role of Classical Signaling Pathways in Stem Cell Maintenance (A Cardoso and N Carlesso
Section Editors
Signal transduction
Stem Cells
Topical Collection on Role of Classical Signaling Pathways in Stem Cell Maintenance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Notch signaling pathway is a well-conserved molecular mechanism that serves the purpose of coordinating cellular events occurring within a group of neighboring cells. The interplay between ligands and receptors of the Notch family is crucial in determining Notch status and the outcome of any specific cellular event often triggered by other signaling pathways. However, different characteristics of the cells involved can also determine their capacity to send or receive specific signals. We have revised how Notch integrates some of the instructive signaling pathways to govern cell fate. Understanding how cells communicate and whether Notch positively or negatively regulates this process is critical for better understanding the mechanisms of cell and tissue homeostasis, which is relevant for regenerative medicine.
ISSN:2198-7866
2198-7866
DOI:10.1007/s40778-016-0065-1