A double‐blind placebo‐controlled randomized trial on the effect of hyosine n‐butyl bromide for improving duration of labor in term pregnancies

• Published in: The journal of obstetrics and gynaecology research 2020-06, Vol.46 (6), p.890-898
• Main Authors: Ejikeme, Toochukwu Benjamin, Eleje, George Uchenna, Igberase, Gabriel O., Ugwu, Emmanuel Onyebuchi, Ikwuka, David Chibuike, Okpala, Boniface Chukwuneme
• Format: Article
• Language: English
• Subjects: Adult; Childbirth & labor; Double-Blind Method; Double-blind studies; Dystocia - drug therapy; Female; Humans; Hydrocarbons, Brominated - administration & dosage; Hydrocarbons, Brominated - pharmacology; hyocine n‐butyl bromide; Injection; Injections; labor; Labor Stage, First - drug effects; Labor Stage, Second - drug effects; Neonates; Nigeria; parturients; Pregnancy; prolonged; Scopolamine - administration & dosage; Scopolamine - pharmacology; Time Factors
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.14251

Aim To compare the effectiveness of intramuscular hyocine n‐butyl bromide (HBB) with placebo for shortening the duration of the first stage of labor in term pregnancies. Methods A double blind placebo‐controlled randomized trial of parturients who presented at term in the active phase of labor was conducted. They were randomly (1:1 ratio) given intramuscular injection of either 40 mg (2 mL) of HBB or 2 mL of water for injection as a placebo. The primary outcome measures were the duration of first and second stages of labor. Subgroup analysis of primigravid and multigravid women were also performed for various outcomes. We did intention‐to‐treat analysis. Results Sixty‐two women were randomized to each group and none were lost to follow‐up. Baseline characteristics were similar between the HBB and placebo groups. The mean duration of first stage of labor was noted to be significantly shorter in the HBB group for both the primigravidas (246.6 ± 21.9 vs 391.8 ± 56.6 min for control; P