Calixarene‐Based Supramolecular AIE Dots with Highly Inhibited Nonradiative Decay and Intersystem Crossing for Ultrasensitive Fluorescence Image‐Guided Cancer Surgery

Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-06, Vol.59 (25), p.10008-10012
Main Authors: Chen, Chao, Ni, Xiang, Tian, Han‐Wen, Liu, Qian, Guo, Dong‐Sheng, Ding, Dan
Format: Article
Language:English
Subjects:
aggregation-induced emission
Animals
Biocompatibility
Calixarenes
Calixarenes - chemistry
Calixarenes - toxicity
Cancer
Cancer surgery
Carcinoma - pathology
Cytotoxicity
Deactivation
Emission
Emissions
Energy dissipation
Fluorescence
fluorescence-guided surgery
Fluorescent Dyes - chemistry
Fluorescent Dyes - toxicity
Gastric cancer
In vivo methods and tests
Mice
nanodots
Nanostructures
Neoplasms - surgery
Optical Imaging
Peritoneum
Reactive oxygen species
supramolecular nanoparticles
Surgery
Surgery, Computer-Assisted - methods
Toxicity
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Summary:Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing and thermal deactivation, enabling the absorbed excitation energy to mostly focus on fluorescence emission. The co‐assembly of calix[5]arene amphiphiles and AIEgens affords highly emissive supramolecular AIE nanodots thanks to their interaction severely restricting the intramolecular motion of AIEgens, which also show negligible generation of cytotoxic reactive oxygen species. In vivo studies with a peritoneal carcinomatosis‐bearing mouse model indicate that such supramolecular AIE dots have rather low in vivo side toxicity and can serve as a superior fluorescent bioprobe for ultrasensitive fluorescence image‐guided cancer surgery. Calix[5]arene‐based supramolecular AIE nanodots were synthesized with high quantum yields in water by virtue of the host–guest complexation. The absorbed excitation energy was mostly focused on fluorescence emission, leading to an ultrahigh signal‐to‐background ratio in fluorescence‐image‐guided cancer surgery.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201916430