The derived neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in patients with angioimmunoblastic T‐cell lymphoma

• Published in: British journal of haematology 2020-06, Vol.189 (5), p.908-912
• Main Authors: Hong, Huangming, Fang, Xiaojie, Huang, He, Wang, Zhao, Lin, Tongyu, Yao, Herui
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; AITL; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Combined Modality Therapy; Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Female; Hematology; Hematopoietic Stem Cell Transplantation; Hemoglobin; Hemoglobins - analysis; Humans; Immunoblastic Lymphadenopathy - blood; Immunoblastic Lymphadenopathy - drug therapy; Immunoblastic Lymphadenopathy - mortality; Immunoblastic Lymphadenopathy - therapy; Inflammation; Inflammation - blood; Leukocyte Count; Lymphocyte Count; Lymphocytes; Lymphoma; Lymphoma, T-Cell, Peripheral - blood; Lymphoma, T-Cell, Peripheral - drug therapy; Lymphoma, T-Cell, Peripheral - mortality; Lymphoma, T-Cell, Peripheral - therapy; Male; Medical prognosis; Middle Aged; Multivariate analysis; Neutrophils; Platelet Count; Platelets; Prednisolone - administration & dosage; Prognosis; progression; Progression-Free Survival; Proportional Hazards Models; Retrospective Studies; risk factors; survival; T-cell lymphoma; Transplantation, Autologous; Treatment Outcome; Vincristine - administration & dosage
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/bjh.16447

Summary To determine whether inflammatory markers, derived neutrophil‐to‐lymphocyte ratio (dNLR), haemoglobin/platelet ratio (HPR) or platelet/lymphocyte ratio (PLR) are predictive for prognosis in angioimmunoblastic T‐cell lymphoma (AITL), we derived dNLR, HPR and PLR values for 110 AITL patients and appropriate cut‐off point values to define overall survival (OS) and progression‐free survival (PFS). dNLR ≥ 2·2, HPR ≥ 0·4 or PLR