Radioprotective effects of montelukast, a selective leukotriene CysLT1 receptor antagonist, against nephrotoxicity induced by gamma radiation in mice

Purpose In this study, we evaluated the renal protective effects of montelukast (MLK) against ionizing radiation (IR) induced nephrotoxicity in mice. Materials and Methods Radioprotective effects of MLK were assessed by biochemical analysis including measurements of kidney malondialdehyde (MDA), red...

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Published in:Journal of biochemical and molecular toxicology 2020-06, Vol.34 (6), p.e22479-n/a
Main Authors: Hormati, Ahmad, Ahmadpour, Sajjad, Afkhami Ardekani, Mahdieh, Khodadust, Fatemeh, Refahi, Soheila
Format: Article
Language:English
Subjects:
Acetates - administration & dosage
Animals
Antioxidants
Antioxidants - administration & dosage
Biochemical analysis
biochemical assays
biodistribution
Creatinine
Creatinine - blood
Creatinine - urine
Cyclopropanes - administration & dosage
Evaluation
Gamma rays
Gamma Rays - adverse effects
Glutathione
Glutathione - analysis
Glutathione - metabolism
Ionizing radiation
Kidney - metabolism
Kidneys
Leukotriene Antagonists - administration & dosage
Male
Malondialdehyde
Malondialdehyde - analysis
Malondialdehyde - metabolism
Mice
Mice, Inbred BALB C
Montelukast
Quinolines - administration & dosage
Radiation therapy
Radiation-Protective Agents - administration & dosage
radioprotective
radiotherapy
Radiotherapy - adverse effects
Reagents
Receptors, Leukotriene
Renal Insufficiency - blood
Renal Insufficiency - drug therapy
Renal Insufficiency - etiology
Renal Insufficiency - urine
Statistical analysis
Sulfides - administration & dosage
Toluene
Urea
Ureas
γ Radiation
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Summary:Purpose In this study, we evaluated the renal protective effects of montelukast (MLK) against ionizing radiation (IR) induced nephrotoxicity in mice. Materials and Methods Radioprotective effects of MLK were assessed by biochemical analysis including measurements of kidney malondialdehyde (MDA), reduced glutathione (GSH), and serum creatinine and urea levels. Besides, for further evaluation of protective effects of MLK on renal system, 99mTc‐dimercaptosuccinic acid (DMSA) has been applied. The total antioxidant capacity of MLK was measured by using 1,1‐diphenyl‐2‐picryl hydrazyl radical reagents and compared with butylated hydroxyl toluene standard antioxidant. Results The biochemical evaluation revealed that better results have been achieved for the groups administered with MLK than the only radiation group. Besides only IR‐treated mice group, those treated with MLK demonstrated a significant decrease in urea and creatinine levels. Statistically, significant differences of MDA and SHG levels (P 
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22479