Recent Advances in Photoredox Methods for Ketone Synthesis

Synthesis of ketones is one of the most addressed problems in organic chemistry owing to their presence in a diverse array of drugs, pharmaceuticals, natural products and photosensitizers. Many of the limitations associated with the traditional approaches enabling the synthesis of ketones like creat...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2020-06, Vol.9 (6), p.863-881
Main Authors: Chalotra, Neha, Sultan, Shaista, Shah, Bhahwal Ali
Format: Article
Language:English
Subjects:
Chemical synthesis
Functional groups
iridium
Ketones
Natural products
Organic chemistry
oxidising agents
photoredox catalysis
Reagents
ruthenium
transition metals
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Summary:Synthesis of ketones is one of the most addressed problems in organic chemistry owing to their presence in a diverse array of drugs, pharmaceuticals, natural products and photosensitizers. Many of the limitations associated with the traditional approaches enabling the synthesis of ketones like creation of high energy acylating reagents, poor functional group tolerance, pre‐activation of starting materials have been largely addressed with the advent of photoredox chemistry. This review summarizes the recent advances made in the photoredox catalyzed synthesis of ketones. This minireview describes recent advances in photoredox methods for ketone synthesis. A varied range of substrates, such as α‐ keto acids, aldehydes, alkenes, alkynes, carboxylic acids, phenols, vinyl azides, acid chlorides and many more, have been employed for the facile synthesis of ketones, accomplished by using different catalytic systems.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202000112