Integrated Ultrasonic Aggregation-Induced Enrichment with Raman Enhancement for Ultrasensitive and Rapid Biosensing

Enrichment and enhancement are two important aspects of ultratrace biomolecule recognition in complex biological samples. Here we integrate acoustic aggregation of modified Au nanorods with Raman enhancement for all-in-one ultratrace rapid biomolecule detection in one microliter solution. Arising fr...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2020-06, Vol.92 (11), p.7816-7821
Main Authors: Xu, Tailin, Luo, Yong, Liu, Conghui, Zhang, Xueji, Wang, Shutao
Format: Article
Language:English
Subjects:
Agglomeration
Analytical chemistry
Biological properties
Biological samples
Biomarkers
Biomolecules
Biosensing Techniques
Biosensors
Chemistry
DNA - analysis
Enrichment
Gold
Gold - chemistry
Humans
Metal Nanoparticles - chemistry
MicroRNAs - blood
Nanoparticles
Nanorods
Nucleic acids
Raman spectra
Rhodamines - analysis
Spectrum Analysis, Raman
Ultrasonic Waves
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Summary:Enrichment and enhancement are two important aspects of ultratrace biomolecule recognition in complex biological samples. Here we integrate acoustic aggregation of modified Au nanorods with Raman enhancement for all-in-one ultratrace rapid biomolecule detection in one microliter solution. Arising from the interaction between individual nanoparticles and the acoustic field, the aggregation of Au nanorods results in rapid migration of specifically modified Au nanorods toward pressure node in a few seconds and accompanies the enrichment of specific biomolecular. As a proof concept, rapid and sensitive surface-enhanced Raman scattering (SERS) detection of nucleic acids (10 M) in microliter-scale (10 L) sample is achieved. Such an approach integrates ultrasonic aggregation-induced enrichment (uAIE) with Raman enhancement, holding considerable promise for efficient, sensitive, and rapid on-chip detection of ultratrace biomarkers in a clinical sample solution.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.0c01011