Effect of Coformers on Novel Co-Crystals of Gabapentin: An In Vivo Approach

Drug readily crosses the blood-brain barrier and enters the central nervous system [2] Pharmacokinetic data Pharmaceutical co-crystals Pharmaceutical co crystals are unit crystalline elements made up of an API and one or more coformer or other API, at room temperature co crystals are solid. Benzoic...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2020-05, Vol.12 (5), p.639-648
Main Authors: Samineni, Ramu, Chimakurthy, Jithendra
Format: Article
Language:English
Subjects:
Acids
Bioavailability
Calibration
Crystals
Drug dosages
Ethanol
Fourier transforms
Methods
NMR
Nuclear magnetic resonance
Pharmaceuticals
Solvents
Spectrum analysis
Studies
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Summary:Drug readily crosses the blood-brain barrier and enters the central nervous system [2] Pharmacokinetic data Pharmaceutical co-crystals Pharmaceutical co crystals are unit crystalline elements made up of an API and one or more coformer or other API, at room temperature co crystals are solid. Benzoic Acid were purchased from the Sigma-Aldrich chemical Pvt. Ltd, Salicylic were purchased from the Merck specialities Pvt. Ltd and Tartaric Acid were purchased from the Thermo Fisher Scientific India Pvt. Ltd. In current research double distilled water, solvents used for analytical grade Methods: Preparation of co-crystal by solvent evaporation: Solution was cooled to room temperature and kept for slow evaporation for 6 h. the crystals were isolated by filtration through a membrane (0.45pm) and dried in the air (102) flow process shown in figure 3, 4 Preparation of co-crystal by solvent drop method: Fourier Transform Infrared spectroscopy (FTIR): FTIR spectra of individual drug, excipients and prepared crystals are recorded by using FTIR spectrophotometer Solvent evaporation, solvent drop and co-grinding methods were employed and the broad spectrum was collected under identical conditions [7].
ISSN:0975-1459