Study of the antidrepanocytary properties of an extract of Ficus umbellata leaves

Prevention; Sickle Cell Disease; Sickle Cell Anemia; Ficus umbellata Several treatment methods have been devised to relieve the sick, among other grafting bone marrow gene therapy, repeated blood transfusions, taking hydroxyurea, etc. MATERIALS AND METHODS The study was started after the approval of...

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Published in:National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2020-01, Vol.10 (6), p.504-507
Main Authors: Ibrahima, Diouf, Sene, Mbaye, Doudou, Diop, Diaw, Absatou, Maimouna, Toure, Mor, Diaw, Khadre, Abdou Sow, Oumy, Ba Kane Modou, Mamadou, Sarr, Abdoulaye, Ba, Aminata, Diallo, Abdoulaye, Samb
Format: Article
Language:English
Subjects:
Flavonoids
Genetic disorders
Hemoglobin
Herbal medicine
Medicine
Physiology
Polymerization
Sickle cell anemia
Sickle cell disease
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Summary:Prevention; Sickle Cell Disease; Sickle Cell Anemia; Ficus umbellata Several treatment methods have been devised to relieve the sick, among other grafting bone marrow gene therapy, repeated blood transfusions, taking hydroxyurea, etc. MATERIALS AND METHODS The study was started after the approval of the university's ethics committee Cheikh Anta Diop in Dakar; blood samples were obtained from AA subjects and other carriers of sickle cell traits known AS and SS by venipuncture at blood transfusion center of Dakar. Temperature of the water bath 40°C, cooling temperature 21°C Ficus umbellata, and the number of rotation 4000 r/min. [...]the evaporation results in obtaining a dry crude extract ethanolic leaves of F. umbellata. [...]at baseline we have a sickle rate of 47%, after adding the extract to 2.5 mg/ml, we have a sickle rate of 18.1%, and after adding the extract 5 mg/ml, the rate rose to 12% [Figure 4].
ISSN:2320-4672
2231-3206
DOI:10.5455/njpp.2020.10.02054202029042020