Health monitoring scheme‐based Forster resonance energy transfer nanocommunications in the Internet of Biological Nanothings

• Published in: International journal of communication systems 2020-07, Vol.33 (11), p.n/a
• Main Author: Abd El‐atty, Saied M.
• Format: Article
• Language: English
• Subjects: BER; Binding; Bit error rate; Communications systems; Drug delivery systems; Energy transfer; FRET; MIMO; MIMO communication; molecular communication; Nanocommunication; Proteins; Resonance; Wireless communication systems; Wireless communications
• ISSN: 1074-5351; 1099-1131
• DOI: 10.1002/dac.4398

Summary In this paper, a health monitoring approach for a targeted drug delivery (TDD) system taking into consideration the binding of drug to a target cell is proposed. The proposed scheme is mainly based on Forster resonance energy transfer (FRET) nanocommunications and the physical phenomenon such as protein–protein interactions in biological systems, in order to propose a molecular communication system with various forms for single and/or multiple ligand–receptor binding. Inspired by classical wireless communication system, the analysis of proposed scheme in terms of bit error rate (BER) and mutual information between the transmitter nanomachine (TN) and receiver nanomachine (RN) is presented. Subsequently, we are able to obtain a closed‐form expression for BER for the proposed scheme. The proposed scheme can be employed in the promising Internet of Biological Nanothings (IoBNT) paradigm. The numerical results reveal that the proposed scheme with multiple donors multiple acceptors system analogous to multiple input multiple output (MIMO) communication system is a superior scheme for transmission therapeutic drug information with achievable BER. A health monitoring scheme‐based FRET nanocommunication is proposed in this paper. The proposed scheme takes into account the drug–protein binding mechanism, which gives a more realistic method for advanced targeted drug delivery system (ADDS). As the proposed scheme is based on a FRET phenomenon, it is capable of guaranteeing to reduce side effects inside the intrabody network, and thus, it is promoted as a powerful tool in health‐tech‐based IoBNT.