Melatonin Enhances the Chemotherapeutic Effect of Cytarabin in HL-60 Cells

The combined effect of melatonin and cytarabin at low concentration on the cells of acute promyelocytic leukemia HL-60 was studied. It has been shown that the combined effect of these substances led to a decrease in the number of cells by 70% and the mitotic activity index by 75%. It was found that...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2020-04, Vol.14 (2), p.140-145
Main Authors: Lomovsky, A. I., Baburina, Yu. L., Kobyakova, M. I., Fadeev, R. S., Akatov, V. S., Krestinina, O. V.
Format: Article
Language:English
Subjects:
Acute promyeloid leukemia
Anticancer properties
Antitumor activity
Apoptosis
Bcl-2 protein
Biomedical and Life Sciences
Cell Biology
Ion channels
Leukemia
Life Sciences
Melatonin
Mitochondria
Promyeloid leukemia
Proteins
Synergistic effect
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Summary:The combined effect of melatonin and cytarabin at low concentration on the cells of acute promyelocytic leukemia HL-60 was studied. It has been shown that the combined effect of these substances led to a decrease in the number of cells by 70% and the mitotic activity index by 75%. It was found that the combined effect of melatonin and cytarabin also contributed to a decrease in the expression of mitochondrial proteins. It has been demonstrated that the combined use of melatonin with low concentration of cytarabin (2 nM) reduced the expression of the voltage-dependent anion channel (VDAC1). Melatonin in combination with cytarabin similarly affected the expression of translocator protein (TSPO) and antiapoptotic protein Bcl-2. The synergistic effect of melatonin in the combined action with cytarabin has been revealed, which provides an increase in the effectiveness of its antitumor action.
ISSN:1990-7478
1990-7494
DOI:10.1134/S1990747819060072