Presence of Colistin Resistance mcr-4 Gene and Clinically Relevant Antimicrobial Resistance Genes in Sand Samples from a Public Beach

The plasmid-borne mobilized colistin resistance genes ( mcr -like) are related to resistance to polymyxins, which were reintroduced for the treatment of infections caused by multidrug-resistant pathogens. To analyze the presence of clinically relevant antimicrobial resistance genes (ARGs), including...

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Published in:Water, air, and soil pollution air, and soil pollution, 2020-07, Vol.231 (7), Article 321
Main Authors: Furlan, João Pedro Rueda, dos Santos, Lucas David Rodrigues, Ramos, Micaela Santana, Gallo, Inara Fernanda Lage, Stehling, Eliana Guedes
Format: Article
Language:English
Subjects:
Antimicrobial agents
Antimicrobial resistance
Atmospheric Protection/Air Quality Control/Air Pollution
Beaches
Care and treatment
Climate Change/Climate Change Impacts
Colistin
Drug resistance
Drug resistance in microorganisms
Earth and Environmental Science
Environment
Environmental monitoring
Genes
Health aspects
Hydrogeology
Multidrug resistance
Pathogens
Plasmids
Polymyxins
Recreation areas
Recreational areas
Sand
Soil Science & Conservation
Tetracycline
Tetracyclines
Water Quality/Water Pollution
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Summary:The plasmid-borne mobilized colistin resistance genes ( mcr -like) are related to resistance to polymyxins, which were reintroduced for the treatment of infections caused by multidrug-resistant pathogens. To analyze the presence of clinically relevant antimicrobial resistance genes (ARGs), including mcr -like genes and plasmids in a beach, sand samples from a public beach were collected. Fifty-seven amplicons from 22 ARGs [ mcr-4 , bla VIM , bla CTX-M-Gp9 , bla PER , bla CMY , qnrB , qnrS , oqxA , oqxB , sul1 , sul2 , sul3 , floR , cmlA , tetA , tetB , tetC , aadA , ant(2″)-Ia , aph(3′)-Ib , aac(6′)-Ib , and mefAE ] and 18 amplicons from seven plasmid families (IncF repB , IncFIA, IncHI1, IncFIB, IncY, IncN, and ColE-like) were detected. To the best of our knowledge, this is the first report of the mcr-4 gene in Brazil and the first report in the world of mcr-4 gene in a recreation area. This study calls attention to the presence of mcr-4 gene and contribute to the surveillance studies about the mcr -like genes.
ISSN:0049-6979
1573-2932
DOI:10.1007/s11270-020-04707-7