Prospective Applications of Single-Domain Antibodies in Biomedicine

Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine. Techniques to generate specif...

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Bibliographic Details
Published in:Molecular biology (New York) 2020-05, Vol.54 (3), p.317-326
Main Author: Tillib, S. V.
Format: Article
Language:English
Subjects:
Antibodies
Biochemistry
Biomedical and Life Sciences
Diagnosis
Human Genetics
Immunoprophylaxis
Life Sciences
Microbiota
Nanobodies
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Summary:Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine. Techniques to generate specific single-domain recombinant antibodies (nanobodies) and their derivatives have raised great expectations in the past years. The review considers the recent literature data on the use of nanobodies in basic research, diagnosis, and design of new immunotherapeutic agents. Special sections focus on the prospects of using nanobodies as targeted molecules of microbiota components, the use of anti-idiotypic nanobodies, and a search for promising targets for early diagnosis based on nanobodies.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893320030164