Association Between Thyroid Hormone Status and Trace Elements in Serum of Patients with Nodular Goiter

• Published in: Biological trace element research 2020-08, Vol.196 (2), p.393-399
• Main Authors: Kravchenko, Victor I., Andrusyshyna, Iryna M., Luzanchuk, Ihor A., Polumbryk, Maksym O., Tarashchenko, Yuriy M.
• Format: Article
• Language: English
• Subjects: Adult; Adults; Biochemistry; Biomedical and Life Sciences; Biotechnology; Calcium; Comparative analysis; Comparative studies; Control; Copper; Emission measurements; Excretion; Female; Goiter; Goiter, Nodular - blood; Health risk assessment; Hormones; Humans; Inductively coupled plasma; Iodine; Iron; Life Sciences; Low concentrations; Magnesium; Male; Metals, Light - blood; Nutrient deficiency; Nutrition; Oncology; Optical emission spectroscopy; Risk; Selenium; Serum; Spectrometry; Thyroglobulin; Thyroid; Thyroid gland; Thyroid Hormones - blood; Trace elements; Trace Elements - blood; Zinc
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-019-01943-9

The present study investigated the status of calcium and magnesium as well as essential trace elements including iodine, selenium, copper, iron, and zinc in adults residing in the Zhytomyr region of Ukraine. In addition, the relative risk of goiter occurrence was evaluated. In this comparative study, 40 adults without goiter (control group) and 16 adults with diagnosed nodular goiter (NG) were examined. Inductively coupled plasma optical emission spectrometry (ICP-OES) was used for the measurements of Mg, Ca, Se, Zn, Cu, and Fe in serum of patients with NG and control group. Patients with nodular goiter had lower serum values of Ca, Mg, Se, Cu, Fe, and Zn than those in the control group. The presence of mild iodine deficiency was evident in both groups with the median urinary iodine excretion (UIE) 80.5 μg/L in the control group and 64.5 μg/L in goiter group. There was a positive association between goiter presence and low concentration of Ca in serum (odds ratio (OR) = 2.29 (1.26–3.55), p < 0.05) in the NG group. High relative risk of goiter was observed at low concentrations of magnesium (OR = 3.33 (1.39–7.62), p < 0.05) and selenium (OR = 1.63, (1.16–1.78), p < 0.05) in comparison with OR values in the control group. Low concentrations of Ca, Mg, Zn, and Se in serum combined with reduced UIE resulted in the highest risk of goiter (OR = 12.5, (2.15–79.42), p < 0.01). This study proved that Thyroglobulin concentration in serum is the reliable indicator of nodular goiter. We also suggest that a combination of low concentrations of Ca, Mg, Zn, Cu, and Se in blood serum, and reduced iodine concentration in urine resulted in the highest risk of nodular goiter development.