Three-Domain Antibodies against the Tumor Necrosis Factor: Investigation of Their Biological Activity In Vitro

— The aim of this work was to evaluate novel three-domain antibodies consisting of two domains specific for human tumor necrosis factor (hTNF), and of the third domain responsible for binding to myeloid cells. The additional hTNF-binding domain should serve to increase the biological activity of new...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2020-05, Vol.46 (3), p.299-305
Main Authors: Vasilenko, E. A., Gorshkova, E. N., Astrakhantseva, I. V., Nedospasov, S. A., Mokhonov, V. V.
Format: Article
Language:English
Subjects:
Antibodies
Binding
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Domains
Life Sciences
Organic Chemistry
Tumor necrosis factor-TNF
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Description
Summary:— The aim of this work was to evaluate novel three-domain antibodies consisting of two domains specific for human tumor necrosis factor (hTNF), and of the third domain responsible for binding to myeloid cells. The additional hTNF-binding domain should serve to increase the biological activity of new antibodies. Capacity of these proteins to bind hTNF on the macrophage surface and to neutralize its biological activity in vitro was assessed.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162020030218