Synthesis and Anticancer Activity of Functionalized Thieno[2,3-d]pyrimidine Compounds and Their Triazinyl and Tetrazinyl Derivatives

New thienopyrimidine derivatives substituted with amino and hydrazinyl side chains were synthesized starting with 2-hydrazinyl substituted thienopyrimidine as a key compound. The newly synthesized compounds were studied for their anticancer activity against prostate cancer (PC3), lung carcinoma (A54...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2020-05, Vol.46 (3), p.393-402
Main Authors: Walaa I. El-Sofany, Othman, Dalia Ahmed A., Mahran, Asma M., May, El-Manawaty A., El-Sayed, Wael A.
Format: Article
Language:English
Subjects:
Anticancer properties
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Biotechnology
Cancer
Derivatives
Life Sciences
Organic Chemistry
Substitutes
Synthesis
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Summary:New thienopyrimidine derivatives substituted with amino and hydrazinyl side chains were synthesized starting with 2-hydrazinyl substituted thienopyrimidine as a key compound. The newly synthesized compounds were studied for their anticancer activity against prostate cancer (PC3), lung carcinoma (A549), and hepatocellular carcinoma (HepG2) cell lines. Benzothienopyrimidine derivatives incorporating thioxoethanethioamide, pyrimidotetrazine carbothioamide, and hydrazinylglycine moieties exhibited high activities against PC3 or A549 cell lines. In addition, the thienopyrimidotriazine derivatives and their thienopyrimidinone analogues were preferentially active against the two cell lines. A number of the synthesized compounds also revealed moderate activities against PC3 and A549 cell lines.
ISSN:1068-1620
1608-330X
DOI:10.1134/S106816202003005X