Basal ganglia calcification induced by excitotoxicity : an experimental model characterised by electron microscopy and X-ray microanalysis

Activation of glutamate receptors induces an excitotoxic neurodegenerative process characterised in some brain areas by the formation of calcium precipitates. To examine the pathogenesis of basal ganglia calcification (BGC), an improved procedure of X-ray microanalysis was used to study experimental...

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Bibliographic Details
Published in:Acta neuropathologica 1999-09, Vol.98 (3), p.217-225
Main Authors: MAHY, N, PRATS, A, RIVEROS, A, ANDRES, N, BERNAL, F
Format: Article
Language:English
Subjects:
Aluminum Silicates - analysis
Animals
Anthraquinones
Astrocytes
Astrocytes - physiology
Astrocytes - ultrastructure
Basal forebrain
Basal ganglia
Basal Ganglia - chemistry
Basal Ganglia - pathology
Basal Ganglia Diseases - chemically induced
Basal Ganglia Diseases - pathology
Biological and medical sciences
Calcification
Calcification (ectopic)
Calcinosis - pathology
Calcium
Cytoplasm
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Deposits
Disease Models, Animal
Electron microscopy
Electron Probe Microanalysis
Excitotoxicity
Forebrain
Gliosis - pathology
Glutamic acid receptors
Hydroxyapatites - analysis
Ibotenic acid
Male
Medical sciences
Microglia
Microglia - physiology
Microglia - ultrastructure
Microscopy, Electron
Mitochondria
Neurodegenerative Diseases - chemically induced
Neurodegenerative Diseases - pathology
Neurology
Neurotoxins - pharmacology
Organelles
Pathogenesis
Rats
Rats, Sprague-Dawley
X-rays
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Summary:Activation of glutamate receptors induces an excitotoxic neurodegenerative process characterised in some brain areas by the formation of calcium precipitates. To examine the pathogenesis of basal ganglia calcification (BGC), an improved procedure of X-ray microanalysis was used to study experimental excitotoxic calcification in the rat. Three weeks after injection of ibotenic acid (IBO) in the rat basal forebrain, calcified inclusions within hypertrophied astrocytes were characterised. They appeared to form part of a filamentous structure localised in the cytoplasm in association with normal mitochondria and other organelles. Larger inclusions were surrounded by reactive microglia. The main inorganic components in these deposits were Ca and P, frequently accompanied by S. Al, Si and K. The shape and Ca/P molar ratio of the large deposits (>10 microm) indicate that they may be biological apatites. Aluminosilicates were detected as small deposits (
ISSN:0001-6322
1432-0533
DOI:10.1007/s004010051072