Topographic genotyping of colorectal carcinoma: from a molecular carcinogenesis model to clinical relevance

In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes)...

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Bibliographic Details
Published in:Annals of surgical oncology 1997-04, Vol.4 (3), p.269-278
Main Authors: Pricolo, V E, Finkelstein, S D, Bland, K I
Format: Article
Language:English
Subjects:
Carcinogenesis
Carcinoma - etiology
Carcinoma - genetics
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - etiology
Colorectal Neoplasms - genetics
Genes, p53 - genetics
Genes, ras - genetics
Genetic analysis
Genotype
Genotyping
Humans
Medical prognosis
Models, Genetic
Mutation
p53 Protein
Topography
Tumors
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Summary:In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may affect tumor behavior and prognosis (sporadic cases). Our method of topographic genotyping of human colonic carcinomas has shown a correlation between K-ras-2 and p53 mutations and stage at diagnosis as well as long-term survival. Data from other investigators in this field confirm the importance of genetic analysis of human colorectal tumors. These findings are likely to impact management by allowing a more individualized therapeutic approach.
ISSN:1068-9265
1534-4681
DOI:10.1007/BF02306621