Oxidative Modification of Proteins in the Tissues of Rats with Growing Tumors under the Ozone-Photodynamic Treatment

—Ozone-photodynamic effects on tumor growth rate and oxidative modification of proteins in rat tissues were studied using a model of PA kidney carcinoma. It was shown that the developed experimental therapeutic method based on the joint parenteral intraperitoneal administration of an ozonated saline...

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Bibliographic Details
Published in:Biophysics (Oxford) 2020-03, Vol.65 (2), p.319-326
Main Authors: Shcherbatyuk, T. G., Zhukova (Plekhanova), E. S., Nikitina, Ju. V., Gapeyev, A. B.
Format: Article
Language:English
Subjects:
Antioxidants
Biological and Medical Physics
Biophysics
Complex Systems Biophysics
Growth rate
Kidney cancer
Kidneys
Oxidative stress
Ozone
Photodynamic therapy
Physics
Physics and Astronomy
Tumors
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Summary:—Ozone-photodynamic effects on tumor growth rate and oxidative modification of proteins in rat tissues were studied using a model of PA kidney carcinoma. It was shown that the developed experimental therapeutic method based on the joint parenteral intraperitoneal administration of an ozonated saline solution with a concentration of ozone in the ozone–oxygen mixture of 400 μg/L and a 0.3% solution of the Photosens photosensitizer intratumorally with the local action of light with a wavelength of 660 ± 10 nm for 10 min reduced the intensity of tumor growth. Normalization of the prooxidant/antioxidant balance in experimental animals was observed upon combined use of ozonated saline solution and photodynamic therapy.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350920020219