Hantzsch synthesis of bis(1,4-dihydropyridines) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridines) linked to pyrazole units as novel hybrid molecules

A novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine) derivatives which are linked to pyrazole units were prepared via Hantzsch like reaction of the bis-aldehydes with the respective 3-aminocrotonitrile and pyrazolone derivatives.

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Bibliographic Details
Published in:Synthetic communications 2020-07, Vol.50 (13), p.1982-1992
Main Authors: Sanad, Sherif M. H., Hawass, Mahmoud A. E., Elwahy, Ahmed H. M., Abdelhamid, Ismail A.
Format: Article
Language:English
Subjects:
Aldehydes
Bis(1,4-dihydropyridine-3,5-dicarbonitrile)
bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine)
Derivatives
Hantzsch
Pyrazole
pyrazole linker
Pyridines
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Summary:A novel series of bis(1,4-dihydropyridine-3,5-dicarbonitrile) and bis(tetrahydrodipyrazolo[3,4-b:4′,3′-e]pyridine) derivatives which are linked to pyrazole units were prepared via Hantzsch like reaction of the bis-aldehydes with the respective 3-aminocrotonitrile and pyrazolone derivatives.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2020.1761395