40Years of My Venture with CYTOMETRY

Briefly depicted are the publications in CYTOMETRY that received the highest frequency of citations. Among them are seminal papers describing application of metachromatic fluorochrome acridine orange to differentially stain DNA versus RNA or to analyze susceptibility of DNA in situ to denaturation;...

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Bibliographic Details
Published in:Cytometry. Part A 2020-06, Vol.97 (6), p.557-562
Main Author: Darzynkiewicz, Zbigniew
Format: Article
Language:English
Subjects:
Acridine orange
Apoptosis
Cell cycle
Cyclins
Cytometry
Denaturation
Deoxyribonucleic acid
DNA
DNA damage
DNA fragmentation
Documents
Gene expression
Ribonucleic acid
RNA
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Summary:Briefly depicted are the publications in CYTOMETRY that received the highest frequency of citations. Among them are seminal papers describing application of metachromatic fluorochrome acridine orange to differentially stain DNA versus RNA or to analyze susceptibility of DNA in situ to denaturation; both features being markers of different sections of the cell cycle including identification of noncycling quiescent cells. The papers reviewing detection of cyclins D1, E, A or B1, each in relation to cell cycle phase, were also among the highly cited ones. The highest citation rates received publications describing development of the TUNEL methodology to detect apoptotic DNA fragmentation, and more recently expression of ϒH2AX to reveal DNA damage. © 2020 International Society for Advancement of Cytometry
ISSN:1552-4922
1552-4930
DOI:10.1002/cyto.a.24043