Do the Moroccan SARS-CoV-2 genetic diversity hamper the use of the developed universal vaccines in Morocco?

Abstract The SARS-CoV-2 identified as coronavirus species associated with severe acute respiratory syndrome. At the time of writing, the genetic diversity of Moroccan strains of SARS-CoV-2 is poorly documented. The present study aims to analyze and identify the genetic variants of fortyeight Morocca...

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Bibliographic Details
Published in:bioRxiv 2020-12
Main Authors: Laamarti, Meriem, Essabbar, Abdelomunim, Alouane, Tarek, Kartti, Souad, Boumajdi, Nasma, Bendani, Houda, Laamarti, Rokia, Allam, Loubna, Ouadghiri, Mouna, Chemao-Elfihri, Mw, Ghrifi, Fatima, Smyej, Imane, Rahoui, Jalila, Benrahma, Houda, Diawara, Idrissa, Aanniz, Tarik, Naima El Hafidi, Rachid El Jaoudi, Nejjari, Chakib, Amzazi, Saaid, Mentag, Rachid, Belyamani, Lahcen, Ibrahimi, Azeddine
Format: Article
Language:English
Subjects:
Epidemiology
Genetic analysis
Genetic diversity
Genomes
Infections
Mutation
Phylogeny
Severe acute respiratory syndrome coronavirus 2
Spike protein
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Summary:Abstract The SARS-CoV-2 identified as coronavirus species associated with severe acute respiratory syndrome. At the time of writing, the genetic diversity of Moroccan strains of SARS-CoV-2 is poorly documented. The present study aims to analyze and identify the genetic variants of fortyeight Moroccan strains of SARS-CoV-2 collected from mid-March to the end of May and the prediction of their possible sources. Our results revealed 108 mutations in Moroccan SARS-CoV-2, 50% were non-synonymous were present in seven genes (S, M, N, E, ORF1ab, ORF3a, and ORF8) with variable frequencies. Remarkably, eight non-synonymous mutations were predicted to have a deleterious effect for (ORF1ab, ORF3a, and the N protein. The analysis of the haplotype network of Moroccan strains suggests different sources of SARS-CoV-2 infection in Morocco. Likewise, the phylogenetic analysis revealed that these Moroccan strains were closely related to those belonging to the five continents, indicating no specific strain dominating in Morocco. These findings have the potential to lead to new comprehensive investigations combining genomic data, epidemiological information, and clinical characteristics of SARS-CoV-2 patients in Morocco and could indicate that the developed vaccines are likely to be effective against Moroccan strains. Competing Interest Statement The authors have declared no competing interest.
DOI:10.1101/2020.06.30.181123