Review of nutritional status, body composition, and effects of antineoplastic drug disposition

The overall survival for children with cancer in high income countries is excellent. However, there are many disparities that may negatively affect survival, which are particularly problematic in low income countries, such as nutritional status at diagnosis and throughout therapy. Nutritional status...

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Bibliographic Details
Published in:Pediatric blood & cancer 2020-06, Vol.67 (S3), p.e28207-n/a
Main Authors: Wiernikowski, John T., Bernhardt, Melanie Brooke
Format: Article
Language:English
Subjects:
Body composition
Chemotherapy
Dietary supplements
Hematology
Microbiomes
nutrition
Nutritional status
Oncology
pediatric oncology
Pediatrics
pharmacokinetics
Survival
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Summary:The overall survival for children with cancer in high income countries is excellent. However, there are many disparities that may negatively affect survival, which are particularly problematic in low income countries, such as nutritional status at diagnosis and throughout therapy. Nutritional status as well as concomitant foods, supplements, and medications may play a role in overall exposure and response to chemotherapy. Emerging science around the microbiome may also play a role and should be further explored as a contributor to disease progression and therapeutic response. This article highlights some of these issues and proposes additional areas of research relevant to nutritional status and pharmacology that are needed in pediatric oncology.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.28207