Identification of Torque Teno Virus/Torque Teno-Like Minivirus in the Cervical Lymph Nodes of Kikuchi-Fujimoto Lymphadenitis Patients (Histiocytic Necrotizing Lymphadenitis): A Possible Key to Idiopathic Disease

Kikuchi-Fujimoto disease (KFD) is rare, and many infectious agents have been suspected for its etiology. This report presents an interesting case of KFD found with torque teno virus/torque teno minivirus (TTV/TTMV), which closely resembles the circovirus that causes necrotizing lymphadenitis in pigs...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine hub 2020-03, Vol.5 (1), p.1-5
Main Authors: Chong, Yosep, Lee, Ji Young, Kang, Chang Suk, Lee, Eun Jung
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Genetic testing
Hepatitis
histiocytic necrotizing lymphadenitis
kikuchi-fujimoto disease
lymphadenitis
Lymphatic diseases
Lymphatic system
Medical laboratories
Novel Insights from Clinical Practice
Pathology
Patients
torque teno virus/torque teno minivirus
Tuberculosis
Ultrasonic imaging
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kikuchi-Fujimoto disease (KFD) is rare, and many infectious agents have been suspected for its etiology. This report presents an interesting case of KFD found with torque teno virus/torque teno minivirus (TTV/TTMV), which closely resembles the circovirus that causes necrotizing lymphadenitis in pigs. Three Korean patients showed several enlarged lymph nodes in their neck. Quantitative polymerase chain reaction (qPCR) and subsequent DNA sequencing for TTV/TTMV using formalin-fixed paraffin-embedded tissue were performed. Histologic examination demonstrated typical features of KFD. qPCR showed successful amplification of TTV/TTMV, and DNA sequencing confirmed the results. It is the first report of TTV/TTMV presence in three patients with KFD.
ISSN:2296-6870
2296-6862
2296-6870
DOI:10.1159/000506501